GHS Classification Result

Chemical Name：2,4-Dinitrophenol
CAS：51-28-5

Result：
ID: 419
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Division 1.1 Danger H201: Explosive; mass explosion hazard P370+P380: In case of fire: Evacuate area.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P230: Keep wetted with ...
P240: Ground/bond container and receiving equipment.
P250: Do not subject to grinding/shock/.../friction.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P372: Explosion risk in case of fire.
P374: Fight fire with normal precautions from a reasonable distance.
P401: Store ...
P501: Dispose of contents/container to ... 		The substance contains nitro groups, with its oxygen budget calculated at -78. The kick-off temperature is 189degC, while the decomposition energy is 144kJ/g (Bretherick (J) (5th,1998)), which is classified as "Explosive." Classified as Division 1.1 since the substance is assigned to Division 1.1D (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) by the UN Recommendations on the Transport of Dangerous Goods.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classification not possible due to lack of data, though flammable according to ICSC (2004). Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Classified as "explosives". Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 112degC (ICSC, 2004), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - Organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 1.1D and Division 6.1 (UN#0076 Dinitrophenol (dry or wetted with <15% water by weight)) (UN Recommendations on the Transport of Dangerous Goods).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 32mg/kg calculated from the testing data of rat LD50 (oral route) of 30mg/kg (CERI Hazard Data 99-9 (2000)), 49mg/kg and 51mg/kg (Report by the Ministry of Health, Labour and Welfare (2001)).
1 Acute toxicity （Dermal） Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) value of 25mg/kg (CERI Hazard Data 99-9 (2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		The substance is classified into Category 2 from the viewpoint of safety, based on the description in the report on guinea pig skin irritation tests (ATSDR (1995)): "moderately irritating," though the results of rabbit skin irritation tests suggest the substance is "mildly irritating" (CERI Hazard Data 99-9 (2000)).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Classification not possible due to the insufficiency of data
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in .ATSDR (1995) and NTP DB (Access on April 2006).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment in the absence of existing classification, though ATSDR (1995) presents some toxicity data.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of significant increases in the number of pups stillborn or dying during lactation observed in rat teratogenic studies, described in MOE Risk Assessment vol. 3 (2004) and ATSDR (1995), though no data are available on parental toxicity.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, kidney) Danger H370: Causes damage to organs (nervous system, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies: "crawling observed in both sexes" (Report by the Ministry of Health, Labour and Welfare (2001)), "displayed very mild tubular necrosis" (ATSDR (1995)).The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (cardiovascular system, blood system, visual organs, nervous system, kidney, liver, gastrointestinal tract), Category 2 (testis) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (cardiovascular system, blood system, visual organs, nervous system, kidney, liver, gastrointestinal tract)
H373: May cause damage to organs through prolonged or repeated exposure (testis) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence: "blood effects including hemolytic anemia, neutropenia and eosinophilia were detected as key effects following exposure to 2,4-denitrophenol" (CERI Hazard Data 99-9 (2000)), "over 100 anecdotal cases of cataracts resulting from therapeutic use of 2,4- dinitrophenol were reviewed" (IRIS (1987)), "necrosis of hepatocytes and hemorrhage were found in the liver; destruction of the epithelium lining the renal tubules with hemorrhage into the glomeruli was found in the kidneys; myocarditis was considered to be the cause of death," "the small intestine contained numerous focal hemorrhagic necroses, severe fatty changes and hemorrhagic nephritis were found; the patient complained of weakness and malaise, became delirious and occasionally euphoric, and showed diminished knee-jerk reflex; a fatal case of agranulocytosis occurred" (ATSDR (1995)). Also based on the evidence from animal studies including "pathological changes in the liver and kidneys, and testicular atrophy were noted" (CERI Hazard Data 99-9 (2000)), "reduced locomotor activity, salivation and calcification of the renal cortico-medullary junctions were observed" (MOE Risk Assessment vol. 3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.09mg/L of the fish (Rainbow Trout) (ECETOC TR91 (2003) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=0.7(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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