GHS Classification Result

Chemical Name：2,6-Dinitrotoluene
CAS：606-20-2

Result：
ID: 414
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups with its oxygen budget calculated at -114, and may explode if heated according to ICSC (2004)). Classified as Division 6.1 (UN#3454 (solid) and UN#1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods). Commercial 2,4-dinitrotoluene, which contains about 20% of 2,6-dinitrotoluene, starts to decompose at 250degC -- a process that continues at 280degC (Bretherick (J), 5th, 1998). The decomposition energy stands at about 85% of that of TNT (2,4,6-trinitrotoluene) (5.1kJ/g) (Bretherick (J), 5th, 1998), according to some reports (NFPA, 13th, 2002).
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as flammable according to ICSC (2004). Classified intoo Division 6.1 (UN#3454 (solid) and UN#1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not classified - - - - Containing nitro groups with explosive properties. The substance may explode if heated according to ICSC (2004)). Classified into Division 6.1 (UN#3454 (solid) and 1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#3454 (solid) and 1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 66degC (ICSC, 2004), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#3454 (solid) and 1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 177mg/kg calculated from the testing data of rat LD50 (oral route) of 177mg/kg (MOE Risk Assessment vol. 4 (2005)), 180mg/kg (IARC (1996)), 535mg/kg (SIDS (2005)) and 795mg/kg (CERI Hazard Data 98-15(3) (1998)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the rat LC50 (4 hour inhalation) value of 360mg/L (CERI Hazard Data 98-15(3) (1998)).
2 Skin corrosion/irritation Not classified - - - - Based on the results of rabbit skin irritation tests that suggest no skin irritation (CERI Hazard Data 98-15(3) (1998)).
3 Serious eye damage/eye irritation Not classified - - - - Based on the results of rabbit eye irritation tests that suggest no eye irritation (CERI Hazard Data 98-15(3) (1998)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests and germ/somatic cell mutagenicity tests in vivo, and positive data on somatic cell genotoxicity tests in vivo (unscheduled DNA synthesis tests, DNA bonding tests) and mutagenicity tests in vitro (reverse mutation tests), described in CERI-NITE Hazard Assessment No.51 (2004), NITE Initial Risk Assessment No.51 (2005), CERI Hazard Data 98-15(2) (1999), NTP DB (Access on April 2006), ATSDR (1998), IARC 9 (1975) and DFGOT vol.6 (1994).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Group 2B by IARC (1999), Category B2 by EPA (1990) and Category 2B by the Japan Society for Occupational Health.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of atrophy of the testes along with a reduction in the level of (or lack of) sperm production found in reproductive toxicity studies in mice, described in MOE Risk Assessment vol. 4 (2005) (though no data are available on general toxicity).
8 Specific target organ toxicity - Single exposure Category 1 (liver, nervous system, respiratory system), Category 2 (cardiovascular system, blood system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (liver, nervous system, respiratory system)
H371: May cause damage to organs (cardiovascular system, blood system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Also based on the evidence from animal studies including "widespread centrolobular hepatocyte hemorrhagic necrosis and some deaths" (CERI-NITE Hazard Assessment No.51 (2004)), "died after developing respiratory depression, ataxia and lethargy" (SIDS (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Since the priority rating of the studies on human health effects is 2, the effects on the cardiovascular system and blood system are classified into Category 2. Refer to "Dinitrotoluene (ID_0413, CAS_25321-14-6)."
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, liver), Category 2 (testis, nervous system, kidney, cardiovascular system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (blood system, liver)
H373: May cause damage to organs through prolonged or repeated exposure (testis, nervous system, kidney, cardiovascular system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Also based on the evidence from animal studies "increased extramedullary hematopoiesis in the spleen, testicular atrophy, reduced sperm productivity, hyperplasia of bile-duct epithelium," "paralysis associated with tetany and spasm, anemia, methemoglobinemia, increased platelet, decreased lymphocytes, increased alkaline phosphatase, increased ALT/urea nitrogen, increased extramedullary hematopoiesis in the spleen, hyperplasia of bile-duct epithelium, hepatic degeneration/inflammation, renal degeneration/inflammation, and testicular atrophy were observed" (CERI-NITE Hazard Assessment No.51 (2004)), "hyperplasia of bile-duct epithelium, hepatocyte degeneration and vacuolization were found" (MOE Risk Assessment vol. 4 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (blood system, liver) and Category 2 (testes, nervous system, kidneys). The effects on the cardiovascular system is classified into Category 2 since the priority rating of the referenced study is 2. Refer to "Dinitrotoluene (ID_0413, CAS_25321-14-6)."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 72 hours ErC50=15mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 1997).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=2.1(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(CERI/NITE Hazard Assessment Report, 2004)), it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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