Chemical Name：4-(2,4-dichlorobenzoyl)-1,3-dimethyl-5-pyrazolyl 4-toluenesulfonate
CAS：58011-68-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1978)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1978)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LC50 (inhalation route) value of 2.5mg/L (Agricultural Chemical Registration Data (1992)).
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	Based on the evidence of mild reversible irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1978)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1978)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea pig sensitization tests (Agricultural Chemical Registration Data (1986)).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Based on the absence of data in in vivo assays, though negative results were obtained in in vitro assays (reverse mutation tests and chromosome aberration tests) (Agricultural Chemical Registration Data (1978, 1988)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no evidence of treatment-related incidence of tumor formation observed in mouse carcinogenicity studies (Agricultural Chemical Registration Data (1989)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on parental reproduction and offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1978, 1986)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available.
9	Specific target organ toxicity - Repeated exposure	Category 2 (genitalia)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (genitalia)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "reduced relative weights of the ovary and womb," "endometrial atrophy" (Agricultural Chemical Registration Data (1978)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.53mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.9(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.