GHS Classification Result

Chemical Name:1,1-Dichloro-1-fluoroethane; HCFC-141b
CAS:1717-00-6

Result:
ID: 404
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - Non-flammable (HSDB, 2006)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing fluorine and chlorine (but not oxygen), with the fluorine and chlorine bound to carbon and hydrogen respectively (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available (boiling point: 32degC (Lide, 84th, 2003), test temperature: 55degC)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 (oral route) value of >5,000mg/kg (SIDS (2003)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the LD50 (dermal route) values of >2,000mg/kg (rats) and >2,000mg/kg (rabbits) (SIDS (2003)), obtained in accordance with TG402, and no marked toxic symptoms observed.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Based on the rat LC50 value of 62,100ppm (4 hours), calculated from the testing data of rat LC50 (inhalation of vapour) of 297.6mg/L (4 hours) (SIDS (2003)), 295mg/L (4 hours) (EHC 139 (1992)) and 300.7mg/L (4 hours) (ECETOC JACC 15 (1990)), was lower than 90% of the saturated vapour concentration (763,000ppm) under a saturated vapour pressure of 76.3kPa (25degC) (SIDS (2003)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Based on the results of rabbit skin irritation tests, SIDS (2003) concludes "it is not irritating to the skin." The substance is thus considered non skin irritant.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
SIDS (2003) evaluating eye irritation potential of 1,1-dichloro-1-fluoroethane in rats provides two sets of data: one positive ("mild irritation (conjunctivitis, chemosis, and moderate blood-tinged discharge) with no corneal involvement. All treated eyes of all rabbits were normal by 72 hours after treatment") and one negative. SIDS (2003) concludes "it is only mildly irritating to the eye." The substance is thus considered a mild irritant and placed in Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - SIDS (2003) evaluating skin sensitizing potential of 1,1-dichloro-1-fluoro in guinea pigs concludes "it is not a skin sensitization in the Guinea pig." However, classification is not possible because of the insufficiency of data to determine the presence of sensitization.
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in SIDS (2003) and EHC 139 (1992).
6 Carcinogenicity Classification not possible - - - - Insufficient data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of adverse effects on reproduction and development (including declined fertility and decreased postimplantation loss) at dosing levels toxic to parental animals.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including: "dose level (concentration) producing narcotic effects on 50% of test animals: 62g/m3" (EHC 139 (1992)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 3.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 48 hours LC50=31mg/L of the crustacea (Daphnia magna) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=2.37(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 2-10%(EHC139, 1992)), it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information