GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,2-Dichloro-3-nitrobenzene
CAS：3209-22-1
Result：
| ID: | 401 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though the substance contains nitro groups, with its oxygen budget calculated at -96 |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though classified as "flammable" by ICSC (1999) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though the substance contains nitro groups |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available (melting point: 61degC (ICSC, 1999), test temperature: 140degC) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 381mg/kg representing the lower of the two testing data of rat LD50 (oral route) of 381mg/kg and 512mg/kg (the Ministry of Health, Labour and Welfare (1994)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Based on the description in the report on rabbit skin irritation tests (HSDB (2005)): "The substance induced slight delipidation of the skin surface, with sloughing in days 7-10. At 24 hours, severe erythema and edema were evident. These irritant reactions gradually subsided and there was no injury in depth. The substance is thus considered to possess a severe skin irritation potential" (though the results are not those of 4-hour application). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on multi-generation/germ cell/somatic cell in vivo mutagenicity/genotoxicity tests and no positive data on mutagenicity tests in vitro (several indices), described in the Ministry of Health, Labour and Welfare (1994) and SIDS (2005). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on reproduction and development at doses producing parental toxicity observed in combined studies, described in SIDS (2005) and CERI Hazard Data 2000-42 (2001). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
|
Danger | H370: Causes damage to organs (nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies: "decreased locomotor activity, blepharoptosis, staggering, relaxation of the general muscles, skin achromasia and deep respiration were observed in a dose-dependent manner. Some deaths were observed 1-2 days after administration as the responses increased in severity and respiration weakened" (the Ministry of Health, Labour and Welfare (1994)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney, blood) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies: "hepatocyte swelling, hyaline droplet/vacuolation of the renal tubular epithelium and increased hemosiderin deposition in the spleen were observed. Increases in urinary protein/serum sodium/protein/total cholesterol levels and decreased urea nitrogen levels were noted. In addition, decreased hemoglobin/ hematocrit values and reticulocytosis were detected, suggesting hemolytic anemia" (the Ministry of Health, Labour and Welfare (1994)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 48 hours EC50=1.6mg/L of the crustacea (Daphnia magna) (CERI Hazard Data, 2002). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=83(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 4%(Existing Chemical Safety Inspections Data)), it was classified into Category 2. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |