Chemical Name:3,5-dichloro-N-(1,1-dimethyl-2-propynyl)benzamide
CAS:23950-58-5
ID: | 398 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Classification not possible | - | - | - | - | Classification not possible due to lack of data on the kick-off temperature and decomposition energy, though being an acetylene compound containing a triple bond, with its oxygen budget calculated at -178. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data , though containing a triple bond and chemical groups with self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 229.1degC) (Agricultural Chemical Registration Data). |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Stable to heat (up to 229.1degC) (Agricultural Chemical Registration Data) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 156.2degC (Agricultural Chemical Registration Data)). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1994)). |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rat LD50 (dermal route) value of >3,160mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1994)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >2.1mg/L (Agricultural Chemical Registration Data (1994)). |
2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on the evidence of irritant effects with a Draize score of <=1, which were fully reversed within 72 hours, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1994)). |
3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | Based on the evidence of conjunctival effects with a Draize score of <=1, which cleared up within 4 days, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1994)). |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Not classified | - | - | - | - | No skin sensitizing potential was found in guinea pig sensitization tests employing the Buehler and Maximization methods (Agricultural Chemical Registration Data (1993, 1998)). |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative data in in vitro studies (reverse mutation tests, chromosome aberration tests and UDS tests) and chromosome aberration tests on rat and mouse bone marrow cells in vivo (Agricultural Chemical Registration Data (1994)). |
6 | Carcinogenicity | Not classified | - | - | - | - | There was no evidence of treatment-related incidence of tumor formation observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1994)). |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on parental reproduction and offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1994)). |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Insufficient data available. |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including hyperpigmentation/Glisson capsule abnormalities/cell abnormalities of the liver, degeneration of renal tubular epithelium/glomerular atrophy (Agricultural Chemical Registration Data (1994)). These effects were observed at dosing levels within the guidance value ranges for Category 2. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 72 hours ErC50=3.4mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 2003). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=3.43(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 2. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |