Chemical Name：N,N-diethyl-3-(2,4,6-trimethylphenylsulfonyl)-1H-1,2,4-triazole-1-carboxamide
CAS：125306-83-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1995)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1995)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >1.97mg/L (Agricultural Chemical Registration Data (1995)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1995)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on the evidence of conjunctival effects with a mean score of <=1.0, which disappeared by 48 hours, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1955)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (1997)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro reverse mutation tests, in vitro chromosome aberration tests, and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1995, 2004)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no evidence of treatment-related incidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1995)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	No evidence of fetal effects was seen in teratogenicity studies performed in rats and rabbits. In rat 2-generation reproduction studies, the gestational period and the number of newborn/live born-pups were slightly reduced, and there were decreases in viability index (F2) and female genital tubercle to vaginal opening distance (F1), and the occurrence of hypospadia (F2) at doses inducing a reduction in parental body weight gains.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	In single dose oral toxicity studies in animals, there were no signs or symptoms of toxicity reported other than a reduction in body weight or body weight gain at 5,000mg/kg (Agricultural Chemical Registration Data (1995)).
9	Specific target organ toxicity - Repeated exposure	Category 2 (gastrointestinal tract)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (gastrointestinal tract)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including vacuolization of ciliated epithelial cells in the jejunum (Agricultural Chemical Registration Data (1995)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours ErC50=0.0021mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.21(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.