GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1-Chloro-1,1-difluoroethane; HCFC-142b
CAS：75-68-3
Result：
| ID: | 382 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
The lower explosion limit is 6.2vol% (ICSC (1999)). Classified into Division 2.1 (UN#2517) (UN Recommendations on the Transport of Dangerous Goods) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Classified into Division 2.1(UN#2517) (UN Recommendations on the Transport of Dangerous Goods) |
| 5 | Gases under pressure | Liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | The boiling point is -9degC (HSDB (2006)), and the critical temperature is 137.1degC (HSDB (2006)) - i.e., liquefied gas. Classified into Divisions 2.1 (UN#2517) (UN Recommendations on the Transport of Dangerous Goods) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 (oral route) value of >5,000mg/kg (EHC 139 (1992)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | Based on the rat LC50 (inhalation exposure) value of 128,000ppm (SIDS (2004)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the description in the report on rabbit eye irritation tests (SIDS (2004)): "Slight conjunctival swelling with some discharge," suggesting that the substance is a mild eye irritant. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative result in multi-generation mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (chromosome aberration tests), and the absence of data on germ cell mutagenicity tests in vivo, described in SIDS (2004), EHC 139 (1992) and DFGOT vol. 1 (1990). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible given the insufficiency of data for use in classification, along with the absence of existing classification. |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on genitals observed in two repeated dose toxicity studies (13-week inhalation study in one sex and 2-year inhalation study in both sexes), described in SIDS. A teratogenicity study in rats (inhalation) is also available that suggests delayed ossification of the occipital bones. However, the author concluded the effects were not attributable to the test substance. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | The evidence of adverse effects on respiratory organs, nervous system and death are reported. However, the dosages of all tests (128,000ppm, 200,000ppm, 400,000ppm) exceed the guidance value. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Due to the fact that the lowest dosages of all tests (1,000ppm) exceed the guidance value. |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Due to the fact that the substance is a gas at ordinary temperatures. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96 hours LC50=36mg/L of the fish (Rainbow Trout) (EHC139, 1992). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=1.66(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 3. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |