NITE - Chemical Management Field

GHS Classification Result

Chemical Name：2-chloro-2',6'-diethyl-N-(2-propoxyethyl)acetanilide
CAS：51218-49-6

Result：


ID:	379
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
6	Flammable liquids	Classification not possible	-	-	-	-	Classification not possible due to lack of data
7	Flammable solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Classification not possible	-	-	-	-	Classification not possible due to lack of data
10	Pyrophoric solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test method applicable to liquid substances are not available (test temperature: 140degC).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements)
14	Oxidizing solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Classification not possible due to lack of data

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LD50 (oral route) value of 2,200mg/kg (Agricultural Chemical Registration Data (1983)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >4,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1983)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	The available rat inhalation studies reported the LC50 value of >2.8mg/L, but there are no test data available for higher doses (Agricultural Chemical Registration Data (1983)).
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on test data from rabbit skin irritation studies (Agricultural Chemical Registration Data (1983)): "Moderately irritating."
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on test data from rabbit eye irritation tests (Agricultural Chemical Registration Data (1983)): "The substance induced mild irritation reactions of the conjunctiva, which were reversed within 7 days."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on positive results in guinea pig skin sensitization tests (Agricultural Chemical Registration Data (1986)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro reverse mutation tests, in vitro chromosome aberration tests and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1983, 1985, 1988)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no evidence of treatment-related incidence of tumor formation observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1983, 1985)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction or offspring development observed in rat 3-generation reproduction studies (Agricultural Chemical Registration Data (1985)) and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1983)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No symptoms or signs referable to specific target organs were observed in the available single dose toxicity studies in rats and mice (Agricultural Chemical Registration Data (1983, 1986)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No symptoms or signs referable to specific target organs were observed in the available subacute toxicity studies in rats (Agricultural Chemical Registration Data (1983)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours ErC50=0.0028mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.08 (PHYSPROP Database, 2005)), it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）