Chemical Name：2-chloro-2'-ethyl-N-(2-methoxy-1-methylethyl)-6'-methylacetanilide
CAS：51218-45-2

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LD50 (oral route) value of 2,200mg/kg (Agricultural Chemical Registration Data (1986)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >4,000mg/kg, together with the absence of mortality at the highest dose of 4000mg/kg (Agricultural Chemical Registration Data (1986)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Although no deaths were observed in rats receiving an inhalation dose of 1.75mg/L, there are no test data available for higher doses (Agricultural Chemical Registration Data (1986)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	In rabbit skin irritation tests, the treated animals exhibited a Draize score of 0.34 at 24 hours, but the effects disappeared by 48 hours (Agricultural Chemical Registration Data (1986)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit eye irritation studies (Agricultural Chemical Registration Data (1986)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on positive results in guinea pig skin sensitization tests employing the Optimization test method (Agricultural Chemical Registration Data (1986)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro reverse mutation tests and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1986)), though in vitro chromosome aberration tests showed positive.
6	Carcinogenicity	Not classified	-	-	-	-	There was no evidence of treatment-related incidence of tumor formation observed in 104-week carcinogenicity studies in rats and mice (Agricultural Chemical Registration Data (1986)). Also due to the fact that the substance is classified as Category C by EPA (1993).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1986)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No toxic symptoms or signs referable to specific target organs were observed in the available animal studies (Agricultural Chemical Registration Data (1986)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No toxic symptoms or signs referable to specific target organs were observed at dose levels within the guidance value ranges for Category 2 in the available subacute toxicity studies in rats (Agricultural Chemical Registration Data (2004)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours EbC50=0.1mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.13(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.