GHS Classification Result

Chemical Name：Manganese N,N'-ethylenebis(dithiocarbamate)
CAS：12427-38-2

Result：
ID: 363
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Cannot be classified due to lack of data, though classified as flammable according to ICSC (2003). Assigned to Division 4.2 and Packing Group III (UN#2210 Maneb or Maneb Preparations with not less than 60% maneb, self-heating substance (ICSC (2003))) (UN Recommendations on the Transport of Dangerous Goods). The substance cannot be "Not classified" given the fact that it has subsidiary risks corresponding to Division 4.3 (substance which in contact with water emits flammable gases).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data. Assigned to Division 4.2 and Packing Group III (UN#2210 Maneb or Maneb Preparations with not less than 60% maneb, self-heating substance (ICSC (2003))) (UN Recommendations on the Transport of Dangerous Goods). The substance cannot be "Not classified" given the fact that it has subsidiary risks corresponding to Division 4.3 (substance which in contact with water emits flammable gases).
11 Self-heating substances and mixtures Category 2 Warning H252: Self-heating in large quantities; may catch fire P235+P410: Keep cool. Protect from sunlight.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P407: Maintain air gap between stacks/pallets.
P413: Store bulk masses greater than ... kg/... lbs at temperatures not exceeding ... degC/... degF.
P420: Store away from other materials. 		Assigned to Division 4.2 and Packing Group III (UN#2210 Maneb or Maneb Preparations with not less than 60% maneb, self-heating substance (ICSC (2003))) (UN Recommendations on the Transport of Dangerous Goods).
12 Substances and mixtures which, in contact with water, emit flammable gases Category 3 Warning H261: In contact with water releases flammable gas P231+P232: Handle under inert gas. Protect from moisture.
P370+P378: In case of fire: Use ... for extinction.
P402+P404: Store in a dry place. Store in a closed container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The subsidiary risks of the substance fall into Division 4.3, Packing Group III (UN#2210 Maneb or Maneb Preparations with not less than 60% maneb, substance which in contact with water emits flammable gases (ICSC (2003))) under the UN Recommendations on the Transport of Dangerous Goods, which corresponds to Category 3 of GHS classification. Those containing stabilizers are also classified into Division 4.3, Packing Group III (UN#2968 Maneb or Maneb Preparations (Maneb stabilized against self-heating; substance which in contact with water emits flammable gases)) under the UN Recommendations on the Transport of Dangerous Goods.
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no chlorine, fluorine and oxygen
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: thermally decomposes at 185degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 (oral route) value of 7,950mg/kg (Agricultural Chemical Registration Data (1974)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1977)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LC50 (inhalation route) value of 7.38mg/L (Agricultural Chemical Registration Data (2005)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the evidence of mild skin irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1970)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the evidence of conjunctival effects with a Draize score of 2.8 observed in rabbit eye irritation tests, which were reversed on day 8 (Agricultural Chemical Registration Data (1985)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on positive results in guinea pig skin sensitization studies employing the Maximization method (Agricultural Chemical Registration Data (2005)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro studies (reverse mutation tests, chromosome aberration tests and DNA repair tests) (Agricultural Chemical Registration Data (1975, 1978, 1987)) and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (2005)).
6 Carcinogenicity Not classified - - - - There was no evidence of treatment-related incidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1978)). Also due to the fact that the substance is classified as Category 3 by IARC (1987).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies (Agricultural Chemical Registration Data (1976)) and rabbit teratogenicity studies (Agricultural Chemical Registration Data (1989)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In the available single dose toxicity studies in rats and mice, no clinical signs or symptoms referable to specific target organs were reported at dose levels below the guidance value ranges for Category 2 (Agricultural Chemical Registration Data (1974)), though some toxic effects were observed at higher doses.
9 Specific target organ toxicity - Repeated exposure Category 2 (thyroid, respiratory system, blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (thyroid, respiratory system, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including increased thyroid weights, pathological changes in the thyroid gland, pulmonary hemorrhage, abnormal lung findings, decreases in RBC/Hb/hematocrit and increase in platelet count, red blood cell deformity, and hyperplasia of thyroid follicular cells (Agricultural Chemical Registration Data (1974, 2005)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=0.189mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=0.62(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 1%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information