GHS Classification Result

Chemical Name:Zinc N,N'-ethylenebis(dithiocarbamate); Zineb
CAS:12122-67-7

Result:
ID: 362
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as flammable according to ICSC (2004). Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Not classified - - - - Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 0.922mg/L (25degC) (Agricultural Chemical Registration Data))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Test methods applicable to solid substances with melting point of >55degC are not available (decomposes at 190degC (Agricultural Chemical Registration Data)). Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1985)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality at doses of >2,000mg/kg (Agricultural Chemical Registration Data (1988)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - A rat acute toxicity study (inhalation route) yielded LC50 of >2.9mg/L. However, there are no data available for doses of 2.9mg/L or greater (Agricultural Chemical Registration Data (1993)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (1970)): "The substance induced very mild irritation, which persisted by 72 hours."
3 Serious eye damage/eye irritation Not classified - - - - Based on the data from rabbit eye irritation tests (Agricultural Chemical Registration Data (1985)): "Non-irritating to the eye."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the data from guinea pig skin sensitization tests using the Maximization method (Agricultural Chemical Registration Data (1976)): "Sensitization: positive."
5 Germ cell mutagenicity Not classified - - - - Based on negative data on in vitro studies (reverse mutation tests, chromosome aberration tests and DNA repair tests) and in vivo mouse genotoxicity tests (host-mediated assay) (Agricultural Chemical Registration Data (1975)).
6 Carcinogenicity Classification not possible - - - - There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, whereas tumor incidence was found in rat 30-month carcinogenicity studies, reported In Agricultural Chemical Registration Data (1978, 1987, 1995). Classification is not possible in the absence of existing classification.
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction and offspring development in rat 2-generation reproduction studies and rabbit teratogenicity studies (Agricultural Chemical Registration Data (1978, 1989)).
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including reduced locomotor activity, crouching position, blepharoptosis or eyelid closure, piloerection, and slightly reduced respiration rate (Agricultural Chemical Registration Data (1985)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the description of the human health effects (EHC 78 (1988)): An epidemiological study on workers engaged in zineb manufacturing was carried out and "among workers occupationally exposed to zineb, the following changes were found...chronic bronchitis (4.4%, versus 0.5% in controls)."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48 hours LC50=0.97mg/L of the crustacea (Daphnia magna) (EHC78, 2001).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=1.3(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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