Chemical Name:Zinc N,N'-ethylenebis(dithiocarbamate); Zineb
CAS:12122-67-7
ID: | 362 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Not classified | - | - | - | - | Classified as flammable according to ICSC (2004). Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods). |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods). |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (water solubility: 0.922mg/L (25degC) (Agricultural Chemical Registration Data)) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Not classified | - | - | - | - | Test methods applicable to solid substances with melting point of >55degC are not available (decomposes at 190degC (Agricultural Chemical Registration Data)). Classified into Division 6.1 (UN#2771 Thiocarbamate Pesticide, solid, toxic (ICSC (2004))) (UN Recommendation on the Transport of Dangerous Goods). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1985)). |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality at doses of >2,000mg/kg (Agricultural Chemical Registration Data (1988)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | A rat acute toxicity study (inhalation route) yielded LC50 of >2.9mg/L. However, there are no data available for doses of 2.9mg/L or greater (Agricultural Chemical Registration Data (1993)). |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (1970)): "The substance induced very mild irritation, which persisted by 72 hours." |
3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | Based on the data from rabbit eye irritation tests (Agricultural Chemical Registration Data (1985)): "Non-irritating to the eye." |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the data from guinea pig skin sensitization tests using the Maximization method (Agricultural Chemical Registration Data (1976)): "Sensitization: positive." | |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative data on in vitro studies (reverse mutation tests, chromosome aberration tests and DNA repair tests) and in vivo mouse genotoxicity tests (host-mediated assay) (Agricultural Chemical Registration Data (1975)). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, whereas tumor incidence was found in rat 30-month carcinogenicity studies, reported In Agricultural Chemical Registration Data (1978, 1987, 1995). Classification is not possible in the absence of existing classification. |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on reproduction and offspring development in rat 2-generation reproduction studies and rabbit teratogenicity studies (Agricultural Chemical Registration Data (1978, 1989)). |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) | Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including reduced locomotor activity, crouching position, blepharoptosis or eyelid closure, piloerection, and slightly reduced respiration rate (Agricultural Chemical Registration Data (1985)). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the description of the human health effects (EHC 78 (1988)): An epidemiological study on workers engaged in zineb manufacturing was carried out and "among workers occupationally exposed to zineb, the following changes were found...chronic bronchitis (4.4%, versus 0.5% in controls)." | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48 hours LC50=0.97mg/L of the crustacea (Daphnia magna) (EHC78, 2001). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=1.3(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |