NITE - Chemical Management Field

GHS Classification Result

Chemical Name：N-(1-Ethylpropyl)-2,6-dinitro-3,4-xylidine; Pendimethalin
CAS：40487-42-1

Result：


ID:	359
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Classification not possible	-	-	-	-	Classification not possible in the absence of data on the decomposition energy, though the substance contains nitro groups with its oxygen budget calculated at -179, and exothermically decomposes at 230-240degC (Agricultural Chemical Registration Data (2004)).
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Classification not possible	-	-	-	-	No data available
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though containing nitro groups with explosive properties
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available (melting point: 57.7-58.0degC (Agricultural Chemical Registration Data (2004)), test temperature: 140degC).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though being organic compounds containing oxygen (but not chlorine and fluorine) bound to the elements other than carbon and hydrogen
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 57.7-58.0degC (Agricultural Chemical Registration Data (2004)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of >10,000mg/kg (Agricultural Chemical Registration Data (1981)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >2,500mg/kg, together with the absence of mortality at the highest dose (Agricultural Chemical Registration Data (1981)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on the rat LC50 (inhalation route) value of >320mg/L (Agricultural Chemical Registration Data (1993)).
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Insufficient data available
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	Insufficient data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea-pig skin sensitization tests using the Buehler method (Agricultural Chemical Registration Data (2005)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on false positive data on in vitro reverse mutation tests, negative in vitro data on chromosome aberration tests, DNA repair tests in vitro (Agricultural Chemical Registration Data (1981)) and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (2005)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1981, 1987)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction and offspring development in rat 3-generation reproduction studies and rat/mouse teratogenicity studies (Agricultural Chemical Registration Data (1981, 1996)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Classification is not possible since no evidence of clinical symptoms which could be used to identify the target organs was observed at doses within the guidance value ranges for Category 2 in the available rat and dog subacute toxicity studies (Agricultural Chemical Registration Data (1995, 2005)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours ErC50=24.3microg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=5.18 (PHYSPROP Database, 2005)), it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）