Chemical Name：O-Ethyl O-(6-nitro-m-tolyl) sec-butylphosphoramidothioate; Butamifos
CAS：36335-67-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 630mg/kg (Agricultural Chemical Registration Data (1981)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1981)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a liquid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible, though no evidence of death was found at the highest dose of 1.2mg/L in rat acute toxicity studies using the inhalation route of exposure (Agricultural Chemical Registration Data (1983)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the data on rabbit skin irritation tests (Agricultural Chemical Registration Data (1981)): "Non-irritating to the skin."
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on the data on rabbit eye irritation tests (Agricultural Chemical Registration Data (1981)): "Non-irritating to the eye."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea-pig skin sensitization studies (Agricultural Chemical Registration Data (1981)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro reverse mutation tests (Agricultural Chemical Registration Data (1981)) and chromosome aberration tests (Agricultural Chemical Registration Data (1989)), and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1989)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1981)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction and offspring development in rat 3-generation reproduction studies (Agricultural Chemical Registration Data (1981)) and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1981, 1989)).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including reduced locomotor activity, abnormal respiration, piloerection, hypersensitivity, salivation, lacrimation, exophthalmos, muscular fasciculations, and limb or generalized ataxia were reported (Agricultural Chemical Registration Data (1981)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In the available rat and mouse subacute toxicity studies (Agricultural Chemical Registration Data (1981, 1985)), cholinesterase inhibition and reduced body weight gains were reported. However, classification is not possible since no evidence of other general symptoms or pathological findings was observed at the doses tested.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours EbC50=17microg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.62 (PHYSPROP Database, 2005)), it was classified into Category 1.