NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Dodecylbenzenesulphonic acid (C12)
CAS：27176-87-0

Result：


ID:	344
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" or "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" or "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" or "solid" according to GHS definition
6	Flammable liquids	Not classified (as a liquid)	-	-	-	-	The flash point is 148.9degC (open cup flash test) (ICSC (2002))
7	Flammable solids	Not classified (as a solid)	-	-	-	-	Classified into Class 8 (UN#2585 Alkyl sulfonic acids (solid) or Aryl sulfonic acids (solid) (with not more than 5% free sulfuric acid)) (UN Recommendation on the Transport of Dangerous Goods).
8	Self-reactive substances and mixtures	Not classified	-	-	-	-	No data available, though being sulfonyls, containing chemical groups with self-reactive properties. Classified into Class 8 (UN#2585 Alkyl sulfonic acids (solid) or Aryl sulfonic acids (solid) (with not more than 5% free sulfuric acid), UN#2586 Alkyl sulfonic acids (liquid) or Aryl sulfonic acids (liquid) (with not more than 5% free sulfuric acid)) (UN Recommendation on the Transport of Dangerous Goods).
9	Pyrophoric liquids	Not classified (as a liquid)	-	-	-	-	Classified into Class 8 (UN#2586 Alkyl sulfonic acids (liquid) or Aryl sulfonic acids (liquid) (with not more than 5% free sulfuric acid)) (UN Recommendation on the Transport of Dangerous Goods).
10	Pyrophoric solids	Not classified (as a solid)	-	-	-	-	Classified into Class 8 (UN#2585 Alkyl sulfonic acids (solid) or Aryl sulfonic acids (solid) (with not more than 5% free sulfuric acid)) (UN Recommendation on the Transport of Dangerous Goods).
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	No data available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Stable to water (readily soluble, ICSC (2002))
13	Oxidizing liquids	Not classified (as a liquid)	-	-	-	-	No data available, though being organic compounds containing oxygen bound to the elements other than carbon and hydrogen. Classified into Class 8 (UN#2586 Alkyl sulfonic acids (liquid) or Aryl sulfonic acids (liquid) (with not more than 5% free sulfuric acid)) (UN Recommendation on the Transport of Dangerous Goods).
14	Oxidizing solids	Not classified (as a solid)	-	-	-	-	Organic compounds containing oxygen bound to the elements other than carbon and hydrogen. Classified into Class 8 (UN#2585 Alkyl sulfonic acids (solid) or Aryl sulfonic acids (solid) (with not more than 5% free sulfuric acid)) (UN Recommendation on the Transport of Dangerous Goods).
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Classification not possible due to lack of data though the substance acts on metals and should not be transported in a metal container (ICSC (2002)). Classified into "Corrosive Substances" by the UN Recommendations on the Transport of Dangerous Goods. However, the category includes skin corrosivity, and it is unclear whether the substance is classified as "metal" corrosive (UN#2585 Alkyl sulfonic acids (solid) or Aryl sulfonic acids (solid) (with not more than 5% free sulfuric acid), UN#2586 Alkyl sulfonic acids (liquid) or Aryl sulfonic acids (liquid) (with not more than 5% free sulfuric acid)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 650mg/kg representing the lower of the two testing data, 650mg/kg (RTECS (2006)) and 1,260mg/kg (IUCLID (2000)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "liquid" or "solid"according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on the description in ICSC (2002) of the human health effects: "redness, pains, skin burn and bullae." The substance is classified into Category 2 because the severity of the effects is unknown.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Based on the description in ICSC (2002) of the human health effects: "redness, pains, skin burn and blindness."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on the description in the report on guinea pig skin sensitization tests (CERI Hazard Data 2001-20 (2002) and CERI-NITE Hazard Assessment No.5 (2004)): "Skin sensitization: positive" (linear alkylbenzenesulfonate and its salts (the carbon chain length unknown); No data available on dodecylbenzenesulphonic acid per se).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to the insufficiency of data (no definite data are available regarding dodecylbenzenesulphonic acid per se). As for linear alkylbenzene sulphonate (LAS) and its salts [carbon chain lengths of 10-14 and their mixtures], no data are available on germ cell mutagenicity tests in vivo, whereas multi-generation mutagenicity tests (dominant lethal tests), somatic cell mutagenicity tests in vivo (micronucleus tests, chromosome aberration tests) and Ames assay gave negative results, described in NTP DB (Access on June, 2006), CERI-NITE Hazard Assessment No.5 (2005) and EHC 169 (1996).
6	Carcinogenicity	Classification not possible	-	-	-	-	Classification not possible based on expert judgment in the absence of existing classification together with the absence of definite data on dodecylbenzenesulphonic acid per se. CERI-NITE Hazard Assessment No.5 (2005) presents some data regarding carcinogenicity studies on linear alkylbenzene sulphonate (LAS) and its salts [carbon chain lengths of 10-14 and their mixtures].
7	Reproductive toxicity	Classification not possible	-	-	-	-	Classification not possible due to the insufficiency of data (no definite data are available regarding dodecylbenzenesulphonic acid per se). As for linear alkylbenzene sulphonate (LAS) and its salts [carbon chain lengths of 10-14 and their mixtures], there was no evidence of adverse effects on the parental animals and the offspring observed in oral studies, whereas decreased fertility and increased incidence of malformation in the offspring were observed at doses inducing parental toxicity in dermal studies, described in CERI-NITE Hazard Assessment No.5 (2005) and EHC 169 (1996).
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory system)		Warning	H371: May cause damage to organs (respiratory system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the description in (ICSC (J) (2002)): "Corrosive to the respiratory tract; oral ingestion results in corrosion." Since the priority rating of ICSC (J) is 2, the effects are classified into Category 2. Note: As for linear alkylbenzene sulphonate (LAS) and its salts [carbon chain lengths of 10-14 and their mixtures], "clinical symptoms include confusion, vomiting, pharyngal and oral pains, and the tendency of blood pressure to decrease" (NITE Initial Risk Assessment No.5 (2005)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Classification not possible due to the fact that the only available data are those for mixtures of C10-14.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 2 from 48 hours LC50=3.5mg/L of the crustacea (Daphnia magna) (EHC169 (1996) and others.). [NOTE]Since it may show same behavior of sodium salt in the environment, it was classified by the data of sodium dodecylbenzenesulfonate(C12).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Since there was rapidly degrading (the decomposition of p-n-dodecylbenzenesulfonic acid sodium salt by BOD: 73% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=1.96(PHYSPROP Database, 2005)), it was claasified into Not classified. [NOTE]Since it may show same behavior of sodium salt in the environment, it was classified by the data of sodium dodecylbenzenesulfonate(C12).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）