GHS Classification Result

Chemical Name：m-Aminophenol
CAS：591-27-5

Result：
ID: 338
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN#2512) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2512) (UN Recommendations on the Transport of Dangerous Goods)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 122-123degC (Merck, 13th, 2001), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) of 920mg/kg (CERI Hazard Data 2001-34 (2002)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) of 1,000mg/kg (CERI Hazard Data 2001-34 (2002)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (RTECS (2004)): "Mild."
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Data 2001-34 (2002)): "moderate irritant."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the positive results in guinea pig skin sensitization tests based on the Maximization method described in CERI Hazard Data 2001-34 (2002), and classified as "skin sensitization" by The Japanese Society for Contact Dermatitis.
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on germ cell mutagenicity tests in vivo, negative data on somatic cell mutagenicity tests in vivo, and negative data on multi-generation mutagenicity tests (dominant lethal tests), described in CERI Hazard Data 2000-34 (2002).
6 Carcinogenicity Classification not possible - - - - Cannot be classified due to lack of existing classification.
7 Reproductive toxicity Classification not possible - - - - Based on the description in CERI Hazard Data 2001-34 (2002): No effects are observed in dams and their offspring. However, classification is not possible because of the absence of data on the reproductive toxicity to males.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system, blood system, liver) Warning H371: May cause damage to organs (nervous system, blood system, liver) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "tremor, salivation, brown urine, abdominal position, achromia of the limbs and auricle, a decrease in locomotor activity focal hepatic necrosis associated with hemolysis caused by the administration of 3-aminophenol" (the Ministry of Health, Labour and Welfare (2001)). The kidneys and spleen, in which the effects are also observed, are not considered as specific target organs because the symptoms are not severe and attributable to hemolysis. The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "brown-black urine due to methemoglobin in the urine" (the Ministry of Health, Labour and Welfare (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=447microg/L of the crustacea (Daphnia magna) (MOE Risk Assessment vol. 2 (2003) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF<40(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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