Chemical Name：2-Amino-4-[hydroxy(methyl)phosphinoyl]butyric acid; Glufosinate
CAS：51276-47-2

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 1,510m/kg (Agricultural Chemical Registration Data (1984)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the absence of mortality at doses of 2,000 and 4,000mg/kg observed in the dermal studies with rats (Agricultural Chemical Registration Data (1984)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LC50 (inhalation route) value of 1.26mg/L (Agricultural Chemical Registration Data (1986)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the evidence of only slight irritation reactions (a mean Draize score of 0.2), which cleared up by 72 hours, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1984)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In rabbit eye irritation tests, the affected animals exhibited the highest Draize score of 1 (conjunctival redness noted at 24 hours); the reactions resolved within 48 hours (Agricultural Chemical Registration Data (1986)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea-pig skin sensitization studies, reported in Agricultural Chemical Registration Data (1986).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on reverse mutation tests in vitro (Agricultural Chemical Registration Data (1986, 2001)) and in vitro chromosome aberration tests (Agricultural Chemical Registration Data (1986)), and micronucleus tests on mouse bone marrow cells in vivo (Agricultural Chemical Registration Data (2004)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1986)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction and offspring development in rat reproduction studies and rat/rabbit teratogenicity studies, reported in Agricultural Chemical Registration Data (1986).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including passivity, impaired sense of equilibrium, prone/lateral position, tremors and convulsions were reported (Agricultural Chemical Registration Data (1984)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In rat subacute toxicity studies, reduced body weight gains associated with decreased food consumption, and increased kidney weight were seen. However, classification is not possible since no other general symptoms or pathological findings were reported (Agricultural Chemical Registration Data (1986)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available