GHS Classification Result

Chemical Name：Bis(2-ehtylhexyl) adipate
CAS：103-23-1

Result：
ID: 334
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 181degC (open cup flash test) (ICSC, 2001)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 395degC (ICSC, 2001)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 (oral route) value of 9,100mg/kg representing the lower of the two testing data, 9,100mg/kg (MOE Risk Assessment vol. 2, 2003) and 25,000mg/kg (IARC 77 (2000)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 (dermal route) of 14,752mg/kg (MOE Risk Assessment vol. 2 (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in CERI Hazard Data 97-12 (1998) (Rabbit primary skin irritation tests indicate slight erythema, which disappears after 72 hours of exposure: Category 3) and MOE Risk Assessment vol. 2 (2003) (Animal studies indicate no skin irritation: Not Classified). Classified as "Category 3" from the viewpoint of safety.
3 Serious eye damage/eye irritation Classification not possible - - - - Based on the text in MOE Risk Assessment vol. 2 (2003): Animal studies indicate no skin/eye irritation. However, classification is not possible because of the lack of data serving as a basis for "Not Classified."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Guinea pig skin sensitization tests (CERI Hazard Data 97-12 (1998), MOE Risk Assessment vol. 2 (2003)) indicate no skin sensitization. However, classification is not possible because of a limited number of test results (with details of which unknown) and the absence of epidemiological findings.
5 Germ cell mutagenicity Not classified - - - - Based on the slight positive data on germ cell multi-generation tests in vivo (dominant lethal tests). However, the dosage is 9,220mg/kg (which exceeds the upper limit of the current guidelines) and the results are based on intraperitoneal administration; the biological significance of slight responsiveness, if any, should be negligible, and hence should be considered "negative." Also based on the absence of data on germ cell mutagenicity tests in vivo, and the negative data on somatic mutagenicity tests in vivo, described in IARC 29 (1982) and IARC 77 (2000).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category 3 by IARC 77 (2000) and Group C by EPA (1994).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in MOE Risk Assessment vol. 2 (2003) and IARC 77 (2000): rat one-generation test suggested body weight/length reduction of the embryo at dosing levels toxic to parental animals; rat teratogenicity tests in suggest dose-dependent ureteral malformations (expansion and convolution) in the embryo, with no description of the general toxicity to parental animals.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Since acute toxicity is not reported within the aqueous solubility concentrations (0.0032mg/L (SIDS (2002))), it was classified into Not classified.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 71% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (BCF=27 (CERI/NITE Hazard Assessment Report (preliminary version), 2006)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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