Chemical Name：2-Methyl-1,1'-biphenyl-3-ylmethyl (Z)-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate; Bifenthrin
CAS：82657-04-3

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 47mg/kg (Agricultural Chemical Registration Data (2004)).
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (dermal route) value of 790mg/kg (Agricultural Chemical Registration Data (2001)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (inhalation route) value of 0.8mg/L (Agricultural Chemical Registration Data (2004)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit skin irritation tests, reported in Agricultural Chemical Registration Data (1991).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In rabbit eye irritation tests, mild irritation was found, with a Draize score of <=1 in all affected animals. The effects resolved within 48 hours (Agricultural Chemical Registration Data (1991)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea-pig skin sensitization studies (Agricultural Chemical Registration Data (1991)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on no evidence of mutagenicity observed in any of the following studies: reverse mutation tests on bacteria, forward mutation tests on CHO cells, unscheduled DNA synthesis tests on primary cultured rat hepatocytes, chromosome aberration tests on CHO cells, and chromosome aberration tests on rat bone marrow cells in vivo (Agricultural Chemical Registration Data (1991)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1991)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction and offspring development in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies, reported in Agricultural Chemical Registration Data (1991).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including increased response to auditory stimuli, altered locomotor activity, lateral position, clonic convulsions and salivation were seen (Agricultural Chemical Registration Data (2001)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In dog repeated dose toxicity studies, tremors were noticed (Agricultural Chemical Registration Data (1991)). The effects were observed at dosing levels within the guidance value ranges for Category 1.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.11microg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2001).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=6 (PHYSPROP Database, 2005)), it was classified into Category 1.