GHS Classification Result

Chemical Name:2-(4-Bromodifluoromethoxyphenyl)-2-methylpropyl 3-phenoxybenzyl ether; Hhalfenprox
CAS:111872-58-3

Result:
ID: 331
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 272degC (Agricultural Chemical Registration Data)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Not classified - - - - Stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing fluorine and oxygen (but not chlorine), with the fluorine and oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 132mg/kg (Agricultural Chemical Registration Data (1993)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the absence of mortality at the highest dose of 2,000mg/kg observed in the dermal studies with rats (Agricultural Chemical Registration Data (1993)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a liquid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LC50 (inhalation route) value of 0.36mg/L (Agricultural Chemical Registration Data (1993)).
2 Skin corrosion/irritation Not classified - - - - Based on the evidence of only mild irritation reactions with a Draize score of 0.05, which healed within 48 hours, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1993)).
3 Serious eye damage/eye irritation Not classified - - - - Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (1993)): "Only mild irritation was seen immediately after the application with a Draize score of 0.2 at 24 hours, and the reactions cleared up by 48 hours." The substance is thus considered non-irritating to the skin.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - No skin sensitizing potential was found in guinea-pig skin sensitization studies, reported in Agricultural Chemical Registration Data (1993).
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on in vivo studies, though in vitro reverse mutation tests, DNA repair tests and chromosome aberration tests yielded negative results (Agricultural Chemical Registration Data (1993)).
6 Carcinogenicity Not classified - - - - There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1993)).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction and offspring development in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies, reported in Agricultural Chemical Registration Data (1993).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
In rat single dose toxicity studies, clinical signs and symptoms including abnormal postures, abnormal gait and tremors were noticed (Agricultural Chemical Registration Data (1993)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, blood system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including convulsions, increased hematopoiesis associated with anemia (Agricultural Chemical Registration Data (1993)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=0.0035ppm of the fish (Carp) (Agricultural Chemical Registration Data, 1993).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.1 (PHYSPROP Database, 2005)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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