GHS Classification Result

Chemical Name：Dithallium sulfate
CAS：7446-18-6

Result：
ID: 328
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2004)
8 Self-reactive substances and mixtures Not classified - - - - No data available, though sulfonyls, containing chemical groups with self-reactive properties. Clasified into Division 6.1 (UN#1707 Thallium compounds (excluding those with specific product names, and pesticides) (ICSC, 2004)) (UN Recommendation on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (ICSC, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 4.87g/100mL (20degC), ICSC (2004))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being inorganic compounds containing oxygen. Classified into Division 6.1 (UN#1707 Thallium compounds (excluding those with specific product names, and pesticides) (ICSC, 2004)) (UN Recommendation on the Transport of Dangerous Goods).
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 10mg/kg calculated from the rat LD50 (oral route) of 10mg/kg, 15mg/kg, 25mg/kg and 76mg/kg (EHC 182 (1996)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) value of 500mg/kg (EHC 182 (1996)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Human epidemiological studies indicate skin irritation potential: "May be absorbed! Redness" (ICSC (2000)). However, classification is not possible as the severity of the effects is not presented.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on human epidemiological studies (ICSC (2000)): "Redness. Pain." Although classified into Category 2A-2B in the absence of data on the severity of the effects, the substance should be placed in Category 2A from the viewpoint of safety if further subclassification is needed.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - No data available
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category D by EPA (1990).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of adverse effects on the testes and pup development (cartilage dysplasia, learning disability) (though no data are available regarding parental toxicity), described in IRIS (2006), EHC 182 (1996), ATSDR (1992), ACGIH (7th, 2001) and PATTY (4th, 1999).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory system, cardiovascular system, skin) Danger H370: Causes damage to organs (nervous system, respiratory system, cardiovascular system, skin) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence: "While the finding of neurological effects was consistent among case reports, death was attributable to cardiac or respiratory failure" (ATSDR (1992)), "thallium intoxication occurred in 48 cases and 26 children exhibited neurological abnormalities when later examined" (ACGIH (7th, 2001)), "a child showed no reflex movements of the legs in the second week, while another child showed no neurological symptoms apart from a massive alopecia in the second week" (EHC 182 (1996)). Also based on the evidence from animal studies: "caused direct effects on the respiratory apparatus, in addition to decreasing vasomotor reactivity" (EHC 182 (1996)), "reported included T-wave fluttering, prolonged Q-T intervals, heart block, atrial and ventricular ectopic rhythms, and ST-segment depression or elevation" (ATSDR (1992)), "may cause alopecia" (ICSC (J)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Refer to "ID0327: Thallium Nitrate (CAS No.10102-45-1)."
9 Specific target organ toxicity - Repeated exposure Category 1 (skin, nervous system, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (skin, nervous system, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies: "induced alopecia," "electrophysiological effect, and about 50% of the animals developed Wallerian degeneration," "there was a dose-related increase in the incidence of alopecia" (EHC 182 (1996)), "the following testicular effects were observed: disarrangement of the tubular epithelium, cytoplasmic vacuolation and distention of the smooth endoplasmic reticulum of the Sertoli cells" (IRIS (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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