Chemical Name:5-Chloro-N-{2-[4-(2-ethoxyethyl)-2,3-dimethylphenoxy]ethyl}-6-ethylpyrimidine-4-amine; Pylimidifen
CAS:105779-78-0
ID: | 326 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available (melting point: 69.4-70.9degC (Agricultural Chemical Registration Data), test temperature: 140degC). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 69.4-70.9degC (Agricultural Chemical Registration Data)). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 115mg/kg (Agricultural Chemical Registration Data (1993)). | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality at doses of >2,000mg/kg (Agricultural Chemical Registration Data (1993)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 | Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LC50 (inhalation route) value of 0.069mg/L (Agricultural Chemical Registration Data (1993)). | |
2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on no evidence of skin irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1993)). |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the data from rabbit eye irritation tests that suggest evidence of mild irritation which cleared up after 2-3 days (Agricultural Chemical Registration Data (1993)). |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on positive results in guinea pig skin sensitization tests using the Maximization method (Agricultural Chemical Registration Data (1996)). | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on in vivo studies, though in vitro reverse mutation tests and chromosome aberration tests showed negative (Agricultural Chemical Registration Data (1993)). |
6 | Carcinogenicity | Not classified | - | - | - | - | There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1993)). |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on reproduction or teratogenicity effects on the pups observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1993)). |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, nervous system) | Danger | H370: Causes damage to organs (respiratory system, nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
In rat and mouse single dose toxicity studies, "hypoactivity" and "bradypnea," "partial eyelid closure," "decreased respiration rate," "gasping" and "open-mouth respiration" were seen (Agricultural Chemical Registration Data (1989)). These effects were observed at dosing levels within the guidance value ranges for Category 1. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver), Category 2 (blood system) |
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (liver) H373: May cause damage to organs through prolonged or repeated exposure (blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "increased liver weight," "hepatocellular swelling" and "anemia" (Agricultural Chemical Registration Data (1993)). These effects were observed at dosing levels within the guidance value ranges for Category 1 (liver) and Category 2 (blood system). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96 hours LC50=0.00211mg/L of the fish (Carp) (Agricultural Chemical Registration Data, 2005). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.84 (PHYSPROP Database, 2005)), it was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |