GHS Classification Result

Chemical Name：2-(1-Methylpropyl)-4,6-dinitrophenol
CAS：88-85-7

Result：
ID: 321
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -140). Classified into Division 6.1 (UN#2779 (Substituted nitrophenol pesticides, solid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classification not possible due to lack of data, though classified as flammable according to ICSC (2004). Classified into Division 6.1 (UN#2779 (Substituted nitrophenol pesticides, solid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing nitro groups with explosive properties. Classified into Division 6.1 (UN#2779 (Substituted nitrophenol pesticides, solid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2779 (Substituted nitrophenol pesticides, solid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 38-42degC (ICSC, 2004), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#2779 (Substituted nitrophenol pesticides, solid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classification not possible due to lack of data, though the substance acts on mild steel in the presence of water, according to HSDB (2006). Classified into Division 6.1 (UN#2779 (Substituted nitrophenol pesticides, solid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 25mg/kg (CERI Hazard Data 2001-15 (2002)).
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 (dermal route) value of 80mg/kg (CERI Hazard Data 2001-15 (2002)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description of the human health effects (CERI Hazard Data 2001-15 (2002)): "Corrosive to the skin." Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Classified as Category 1 in accordance with the technical guideline, given the fact that the substance is classified as "corrosive" for "2. Skin corrosion / irritation" above.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on in vivo tests and no positive data on in vitro mutagenicity tests (several indices), described in CERI Hazard Data 2001-15 (2002).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category D by EPA (1993).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of pup malformation at parentally toxic doses (or in the absence of data on parental toxicity) in teratogenicity studies in mice and rats, along with the evidence of reproduction impairment in rat reproductive toxicity studies, described in CERI Hazard Data 2001-15 (2002).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, kidney), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system, kidney)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence: "directly affects, stimulates and suppresses the cerebrum and lower brain centers; causes necrotic damage to the renal tubules in the kidneys" (CERI Hazard Data 2001-15 (2002)). Also based on the evidence from animal studies including "somnolency, spasm" (RTECS (2006)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney, nervous system, testis, uterus), Category 2 (blood system, visual organs) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, nervous system, testis, uterus)
H373: May cause damage to organs through prolonged or repeated exposure (blood system, visual organs) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence: "the substance has toxic effects on the liver, kidneys and nervous system, and produces degenerative changes in the hepatic parenchyma and renal tubules" (CERI Hazard Data 20001-5 (2002)), "this substance has effects on the kidneys, liver, blood, immune system and eye, may cause cataract; may induce reproductive toxicity in humans" (ICSC (J) (1994)). Also based on the evidence from animal studies: "Histological changes in the testes including abnormal spermatozoa, spermatids and multinucleated spermatogenic cells," "tubular atrophy of testes" (HSDB (2003)), "cystic endometrial hyperplasia and testicular atrophy" (IRIS (1987)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2. The effects on the blood system and visual organ are classified into Category 2 since the priority rating of the referenced study (ICSC (J)) is 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.028mg/L of the fish (American Catfish) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=1(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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