GHS Classification Result

Chemical Name:3,5-Dimethylphenyl N-methylcarbamate; XMC
CAS:2655-14-3

Result:
ID: 320
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 100.9-101.3degC (Agricultural Chemical Registration Data (1999)), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 100.9-101.3degC (Agricultural Chemical Registration Data (1999))).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 542mg/kg (Agricultural Chemical Registration Data (2004)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 (dermal route) value of >=5,000mg/kg (Agricultural Chemical Registration Data (2004)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible since the acute toxicity value cannot be determined, though the available rat inhalation studies yielded the LC50 value of >=1.02mg/L (Agricultural Chemical Registration Data (2004)).
2 Skin corrosion/irritation Not classified - - - - Based on the report on rabbit skin irritation tests (Agricultural Chemical Registration Data): "Non-irritating."
3 Serious eye damage/eye irritation Not classified - - - - Based on the evidence of only slight irritation reactions (a mean Draize score of <=1), with effects resolving by Day 7, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (2004)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on no evidence of sensitization observed in guinea pig skin sensitization tests using the Maximization method, reported in Agricultural Chemical Registration Data (2002).
5 Germ cell mutagenicity Not classified - - - - Based on negative data on in vitro reverse mutagenicity tests, in vitro DNA repair tests and in vivo mouse and rat micronucleus tests, and positive data on in vitro chromosome aberration tests (Agricultural Chemical Registration Data (2004)).
6 Carcinogenicity Classification not possible - - - - Classification not possible in the absence of existing classification, though no evidence of tumor formation was seen in rat 2-year carcinogenicity studies, whereas a slight increase in hepatocellular tumor incidence was observed in females in mouse carcinogenicity studies (Agricultural Chemical Registration Data (2004)).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction and offspring development in rat 3-generation reproduction studies and rat/rabbit teratogenicity studies, reported in Agricultural Chemical Registration Data (2004).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
In rat single dose toxicity studies, clinical signs and symptoms including reduced locomotor activity, gait disorder, tremors, salivation, reduced locomotor activity, blepharoptosis, and crouching position were found (Agricultural Chemical Registration Data (2004)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to the insufficiency of data. In the available rat and mouse 90-day subacute toxicity study, no definitive evidence of treatment-related toxicity was reported (Agricultural Chemical Registration Data (2004)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48 hours EC50=0.0301mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, ).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (BCF=2.5(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 1%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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