GHS Classification Result

Chemical Name:2-Isopropylphenyl N-methylcarbamate; Isoprocarb; MIPC
CAS:2631-40-5

Result:
ID: 319
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 92.2degC (Agricultural Chemical Registration Data), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 92.2degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 178mg/kg (Agricultural Chemical Registration Data (1995)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the absence of mortality at the highest dose of 2,000mg/kg observed in the dermal studies with mice (Agricultural Chemical Registration Data (1995)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible since the acute toxicity value cannot be determined, though there was no evidence of death observed at the highest dose of 2.1mg/L in rat inhalation studies (Agricultural Chemical Registration Data (1995)).
2 Skin corrosion/irritation Not classified - - - - Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (1995)): "Non-irritating to the skin."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (1995)): "The treated animals exhibited irritation reactions of the cornea and conjunctiva, but the reactions resolved by Day 4."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the report on guinea pig Maximization tests (Agricultural Chemical Registration Data (1995)): "Skin sensitization: negative (sensitization rate: 0%).
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on in vivo studies, though in vitro tests (reverse mutation tests, chromosome aberration tests and DNA repair tests) gave negative results (Agricultural Chemical Registration Data (1995)).
6 Carcinogenicity Not classified - - - - There was no treatment-related evidence of tumor formation observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, reported in Agricultural Chemical Registration Data (1995).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction and fetuses observed in rat 3-generation reproduction studies and rat/rabbit teratogenicity studies, reported in Agricultural Chemical Registration Data (1995).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 2 (respiratory system) Danger
Warning
H370: Causes damage to organs (nervous system)
H371: May cause damage to organs (respiratory system)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
In rat single dose toxicity studies, clinical signs and symptoms including reduced locomotor activity, crouching position, lateral position, staggering gait, and tremors were seen at dosing levels within the guidance value ranges for Category 1. At dose levels for Category 2, diffuse white patches were also observed in the lung (Agricultural Chemical Registration Data (1995)).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, liver), Category 2 (kidney) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (blood system, liver)
H373: May cause damage to organs through prolonged or repeated exposure (kidney)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including leukocytosis, anemia, changes in liver and kidney weights, small round cell infiltration of Glisson capsules, and renal interstitial cellular infiltration (Agricultural Chemical Registration Data (1995)). These effects were observed at dosing levels within the guidance value ranges for Category 1 (blood system and liver) and Category 2 (kidneys).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48 hours EC50=24microg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (BCF=15(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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