Chemical Name：N-(4-tert-Butylbenzyl)-4-chloro-3-ethyl-1-methylpyrazole-5-carboxamide; Tebufenpyrad
CAS：119168-77-3

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 595mg/kg (Agricultural Chemical Registration Data (1993)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the absence of mortality at the highest dose of 2,000mg/kg observed in the dermal studies with rats (Agricultural Chemical Registration Data (1993)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LC50 (inhalation route) value of 2.7mg/L (Agricultural Chemical Registration Data (1993)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (1993)): Non-irritating to the skin (Draize score: 0).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on the evidence of moderate eye irritation (a mean Draize score of about 4) in rabbit eye irritation tests, with effects clearing after 72 hours (Agricultural Chemical Registration Data (1993)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on the evidence of sensitization observed in guinea pig Maximization tests (Agricultural Chemical Registration Data (1993)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro reverse mutation tests, forward mutation assay, chromosome aberration tests, DNA repair tests and unscheduled DNA synthesis tests (Agricultural Chemical Registration Data (1993)). Also based on negative data on in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1993)).
6	Carcinogenicity	Classification not possible	-	-	-	-	Classification not possible in the absence of existing classification, though a slight increase in the incidence of hepatocellular adenoma was observed in rat 2-year carcinogenicity studies (Agricultural Chemical Registration Data (1993)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of abortion at doses inducing reduced body weight in parental animals in rabbit teratogenicity studies. Also based on the evidence of reduced fetal development and increased incidence of 14th rib anomalies at doses causing reduced body weight gains in parental animals in rat teratogenicity studies, reported in Agricultural Chemical Registration Data (1993).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	In rat single dose toxicity studies, clinical signs and symptoms including prone position, ataxia, bradypnea, reduced motor activity, loss of consciousness were found (Agricultural Chemical Registration Data (1993)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including changed ALP/gamma-GTP levels, increased relative liver/kidney weight, and perilobular hypertrophy of hepatocytes (Agricultural Chemical Registration Data (1993)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.046mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.61 (PHYSPROP Database, 2005)), it was classified into Category 1.