GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Arsine
CAS：7784-42-1
Result：
| ID: | 312 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
Based on the description in ICSC (2004): the lower explosion limit is 4.5vol%. Classified into Division 2.1 (UN#2188) (UN Recommendations on the Transport of Dangerous Goods) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Classified into Division 2.1 and Division 2.3 (UN#2188) (UN Recommendations on the Transport of Dangerous Goods) |
| 5 | Gases under pressure | Liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | The boiling point is -62degC (ICSC (2004)) and the critical temperature is 100degC (HSDB (2006)), i.e., liquefied gas. Classified into Division 2.1 and Division 2.3 (UN#2188) (UN Recommendations on the Transport of Dangerous Goods). |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gas substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LC50 (inhalation of gas) value of 16.2ppm (4 hours). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3." |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category 1 (as ARSENIC AND ARSENIC COMPOUNDS) by IARC (1987) and Category K (as Arsenic Compounds, Inorganic) by NTP (2005). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3." |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, blood system, cardiovascular system, respiratory system, liver, kidney) |
|
Danger | H370: Causes damage to organs (central nervous system, blood system, cardiovascular system, respiratory system, liver, kidney) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence: "clinical symptoms include transient hemolytic anemia, nausea, headache, anemia, decreased hemoglobin levels, erythema of the skin, jaundice, hemoglobinuria and shock" (IARC 84 (2004)), "pulmonary edema and acute circulatory disorder," "hepatitis on the 20th day after the acute hemolysis" (CICAD 47 (2002)), "hemolysis and nephropathy" (ACGIH (7th, 2001)), and the evidence from animal studies including "a 10.5% reduction in hematocrit levels observed in the 26ppm dose group" (CICAD 47 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "a decrease in hemoglobin level to 32g/L and basophilic stippling (in red blood cells)" (IARC 84 (2004)), and the evidence from animal studies including "anemia (decreased hemoglobin/hematocrit/RBC)" (CICAD 47 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Not applicable |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |