GHS Classification Result

Chemical Name:2-Thioxo-3,5-dimethyltetrahydro-2H-1,3,5-thiadiazine; Dazomet
CAS:533-74-4

Result:
ID: 292
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN#2588 Pesticide, solid, toxic, n.o.s. (ICSC (2000))) (UN Recommendation on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2588 Pesticide, solid, toxic, n.o.s. (ICSC (2000))) (UN Recommendation on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Not classified - - - - Classified into Division 6.1 (UN#2588 Pesticide, solid, toxic, n.o.s. (ICSC (2000))) (UN Recommendation on the Transport of Dangerous Goods).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). The substance decomposes in water or dilute acid, according to Merck (13th, 2001)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 104-105degC, Agricultural Chemical Registration Data).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 550mg/kg (Agricultural Chemical Registration Data (1990)).
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (dermal route) value of 2,260mg/kg (Agricultural Chemical Registration Data (1990)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LC50 (inhalation route) value of 7.29mg/L (Agricultural Chemical Registration Data (1990)).
2 Skin corrosion/irritation Not classified - - - - Based on no evidence of skin irritation observed in rabbit skin irritation studies (Agricultural Chemical Registration Data (1990)).
3 Serious eye damage/eye irritation Not classified - - - - Based on the evidence of very mild irritation (the highest mean Draize score of 0.6 by 72 hours), with effects fully resolving by 72 hours, observed in rabbit eye irritation studies (Agricultural Chemical Registration Data (1990)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on no evidence of skin sensitization observed in guinea pig skin sensitization tests using the Maximization method (Agricultural Chemical Registration Data (1990)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data on in vitro reverse mutagenicity tests, in vitro chromosome aberration tests and in vivo micronucleus tests on mouse bone marrow cells(Agricultural Chemical Registration Data (1990)).
6 Carcinogenicity Not classified - - - - There was no treatment-related increase in tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies, reported in Agricultural Chemical Registration Data (1990).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of increased incidence of postimplantation loss at doses causing an increase in body weight in parental animals observed in rabbit teratogenicity studies (Agricultural Chemical Registration Data (1990)). Since it cannot be concluded that the findings are secondary to parental toxicity, the substance is classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In rat single dose toxicity studies, clinical signs and symptoms including hyperventilation, lacrimation, salivation, reduced locomotor activity, and crouching position were reported (Agricultural Chemical Registration Data (1990)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In rat repeated dose toxicity studies, evidence of fatty degeneration of hepatocytes associated with increased liver weight was found (Agricultural Chemical Registration Data (1990)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=0.16ppm of the fish (Rainbow Trout) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=1.4(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 4%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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