Chemical Name：O,O-Diethyl S-(6-chloro-2,3-dihydro-2-oxobenzoxazolinyl)methyl phosphorodithioate; Phosalone
CAS：2310-17-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the LD50 value of 85mg/kg calculated from the testing data of rat LD50 (oral route) of 85mg/kg (RTECS (2006)), 120mg/kg and 170mg/kg (HSDB (2003)).
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (dermal route) value of 390mg/kg (RTECS (2006)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on the description of the human health effects (HSDB (2003)): "moderately irritating."
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Based on the description of the human health effects (HSDB (2003)): "moderately irritating."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 2 (liver)		Danger Warning	H370: Causes damage to organs (central nervous system) H371: May cause damage to organs (liver)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.	Based on the evidence from animal studies: "like other organophosphorous agents, the substance induces tremor and lacrimation, leading eventually to tonic convulsion before death" (JMPR (1972)), "the liver injury was not only structural but also functional. Clinical symptoms include general depression, discoordination of movements, salivation, muscle disorder, tremor, bronchospasm, paresis, paralysis, and coma" (HSDB (2003)). The effects on experimental animals were observed at dosing levels within guidance value ranges for Categories 1 and 2.
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "myospasm, hypersensitivity and labored respiration" (JMPR 1972). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours LC50=100microg/L of the fish (Bluegill) (HSDB, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.38 (PHYSPROP Database, 2005)), it was classified into Category 1.