Chemical Name：O-Ethyl S,S-diphenyl phosphorodithioate; Edifenphos; EDDP
CAS：17109-49-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 100mg/kg (HSDB (2006) and RTECS (2006)).
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (dermal route) value of 615mg/kg (RTECS (2006)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a liquid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (4 hour inhalation of vapour) value of 0.65mg/L (HSDB (2006)) exceeded 90% of the saturated vapour concentration (3.6*10^(-4)ppm) under a saturated vapour pressure of 2.70*10^(-7)mmHg (25degC) [equivalent to 36.0microPa (25degC)] (HSDB (2006)), the substance was considered as "mist exposure" and was classified as Category 3.
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	Based on the description in the report on rabbit skin irritation tests (exposure duration unknown) (HSDB (2006)): "Slightly irritating."
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	The results of rabbit eye irritation tests suggest that the substance is "not irritating" (HSDB (2006)), that is, "Not classified." However, as the skin irritation effects are assigned Category 3, the substance is considered to possess a mild eye irritation potential and thus classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system), Category 3 (narcotic effects)		Warning	H371: May cause damage to organs (nervous system) H336: May cause drowsiness or dizziness (narcotic effects)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the evidence from animal studies including "lethargy and convulsions" (RTECS (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. However, as the referenced study is assigned a priority rating of 2, which does not meet the criteria for 1b (3) specified in the "Technical Guideline for GHS Health Hazard Classification," the substance is placed in Category 2.
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, adrenal gland), Category 2 (blood system)		Danger Warning	H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, adrenal gland) H373: May cause damage to organs through prolonged or repeated exposure (blood system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies: "hepatocellular hypertrophy, phospholipid deposition, along with adrenal hypertrophy/pigmentation were seen," "decreased RBC/hemoglobin/hematocrit levels, decreased SGOT/SGTP/SAP, hepatocellular hypertrophy/fatty degeneration, nephritis, renal/adrenal hypertrophy were noted" (JMPR (1976)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (liver, kidneys, adrenal) and Category 2 (blood system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.021ppm of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.48(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.