Chemical Name：alpha-Cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate; Cypermethrin
CAS：52315-07-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 195mg/kg (Agricultural Chemical Registration Data (1986)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >5,000mg/kg, together with the absence of mortality at doses of not more than 5,000mg/kg (Agricultural Chemical Registration Data (1986)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible since the available rat inhalation LC50 value of >0.25mg/L is not classifiable (Agricultural Chemical Registration Data (1986)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of local responses observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1986)).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on the evidence of mild irritation (the highest mean Draize score of 2.3) with effects fully reversible by 48 hours, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1986)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	Based on no evidence of skin reactions observed in guinea pig skin sensitization studies (Agricultural Chemical Registration Data (1986)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on in vitro reverse mutation tests, in vivo mouse dominant lethal tests and chinese hamster somatic cell chromosome aberration tests (Agricultural Chemical Registration Data (1986)).
6	Carcinogenicity	Not classified	-	-	-	-	The available carcinogenicity studies in rats and mice provide no evidence of treatment-related increase in the incidence of tumor formation, reported in Agricultural Chemical Registration Data (1986). Also due to the fact that the substance is classified as Group C by EPA.
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproductive function/capacity and pup development observed in 2-generation reproduction studies in rats and gestation studies in rats and mice (Agricultural Chemical Registration Data (1986)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In the oral toxicity studies using rats or mouse, lethargy, sedation, ataxic gait, piloerection, vocalization, rolling, jumping, loose stool and stained fur have been observed with both males and females, and salivation has been observed only with males (Technical Reports for Agricultural Chemical Registration (1986)) within the guidance values for Category 1. So the substance was classified as Category 1 (nervous system) based on these results.
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including self-licking/biting, generalized tremors, rigid gait, ataxia, incoordination, hyperesthesia (Agricultural Chemical Registration Data (1986)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours EC50=0.004microg/L of the crustacea (Amphipod) (EHC82, 1989).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=6.6 (PHYSPROP Database, 2005)), it was classified into Category 1.