GHS Classification Result

Chemical Name：methylhydrazine
CAS：60-34-4

Result：
ID: 245
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification not possible due to lack of data on an exothermic decomposition energy.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 1 Danger H224: Extremely flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		UNRTDG No. 2740, Class: 3; PG I. Flash point: -8.3degC. Boiling point 87.5degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - UNRTDG Non-hazardrous Substance
9 Pyrophoric liquids Not classified - - - - Since it is not classified as UNRTDG class 4.2 PG I and the ignition points was 196 degC (ICSC (J), (2004)), it was presupposed that it does not ignite spontaneously even if it contacts the air of normal temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - Reducing substance (ICSC(J), 2004)
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - It is a moderate strong bases (ICSC (J) (2004)). However, there is no metal corrosion data and it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 32 mg/kg REFERENCE SOURCE: PATTY (4th, 1994)
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LD50 value: 183mg/kg and rabbit LD50 value: 93mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994), the rabbit lower value was adopted and it was set as Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (4 hours) values: 74ppm and 78ppm (equivalent of 0.14mg/L and 0.15mg/L) (ACGIH 7th, 2001, PATTY 4th, 1994) which vapor pressure indicate steam with almost no mist, it was classified as Category 1 by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description that erythema and edema were observed in dog skin application test, though the exposure time was unknown (ACGIH (7th, 2004) and PATTY (4th, 1994)) and that there is possibility of severe damage on human skin (PATTY (4th, 1994)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		It was set as Category 2A from description that damage serious to an eye may be seen by the humans of PATTY (4th, 1994).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although classified into Sh according to DFG, since there was no evidence that hypersensitivity was induced by skin contacts by humans, it did not meet the judgment criteria and it was decided not to be classified due to insufficiency of data.
5 Germ cell mutagenicity Not classified - - - - The substance is regarded as outside the categories. Because there are negative results from the dominant lethal tests in mice, which are in vivo multi-generation mutagenicity tests using germ cells (ACGIH (7th, 2001), PATTY (4th, 1994)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it was classified into A3 (ACGIH 7th, 2001) according to ACGIH, it was set as Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since although there was no descriptions about general toxicity of parent animals, there is the description that there is fetal malformation in oral administration test to pregnancy mouse and rabbit (HSDB (2005)), it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (blood, nervous system) Danger H370: Causes damage to organs (blood, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the descriptions that the effect on the blood was observed in human inhalation exposure example in PATTY (4th, 1994), that the convulsion was observed in the range of guidance value of Category 1 in the oral study using rat, and that the effect on the nervous system was observed in the inhalation exposure test using mouse with unknown concentrations. So it was classified into Category 1 (blood, nervous system) from description that .
9 Specific target organ toxicity - Repeated exposure Category 1 (blood, liver, kidney, respiratory system, adrenal gland) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood, liver, kidney, respiratory system, adrenal gland) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is classfied in Category 1 (blood, liver, kidney, respiratory organs, adrenal gland) from description in ACGIH (7th, 2001) that the influence on liver, the kidney, respiratory organs, or the adrenal gland were seen with the concentration of the guidance value range of Category 1 in the test which carried out inhalation exposure, over a long-term to the rat, the mouse, the dog, hamster, or ape.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=2580microg/Lof fishes (Guppy) (AQUIRE, 2003) .
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2, and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though supposed less bio-accumulative (log Kow=-1.05(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information