Chemical Name：tetrasodium 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate]
CAS：2429-74-5

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	From description that the general lethal doses of rat in HSDB (2006) is 17000mg/kg, it was set as the outside of Category.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	There is possibility of being out of Category from statement that irritation was not observed in the human skin irritation test (HSDB (2006)). But there is a statement that it caused moderate irritation or no irritation in the test on guinea pigs (HSDB (2006)), and there is no statement in Priority 1that clearly negates hazard. So it cannot be classified.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Classification not possible	-	-	-	-	HSDB (2006) describes that no sensitization was found in a test using guinea pigs and a test involving humans. However we classified this as uncategorizable because there was no description that clearly negates sensitization in Priority 1.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 2. Because there is a positive result for the DNA damage test in mice, which is an in vivo genotoxicity test using somatic cells (RTECS, 2006) and there are positive results for the mouse lymphoma assays, which are in vitro mutagenicity tests, when S9 is present (IARC 57, 1993, NTP TR397, 1992)
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It is classified into group 2B (IARC 57, 1993) according to IARC and is classified into 2B (Japan Society for Occupational Health recommendation, 2005) in Japan Society for Occupational Health. So it was set as Category 2.
7	Reproductive toxicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Not classified	-	-	-	-	From the descriptions in IARC 57 (1993) and NTP TR397 (1992) that influence was not seen with even 4-time-as much dose as the guidance value range maximum of Category 2 in an oral study for 90 days using the rat, it was referred to as outside the category.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available