GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Tetramethyl silicate
CAS：681-84-5
Result：
| ID: | 226 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified (Category 2 or Category 3) |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
There are deviations in the flash point data, and the assays is also not known. Therefore, if the flash point is not measured with a real sample, it cannot be judged. The acceptance criteria are as follows: Category 2: flash point <23 degC; Category 3: 23 degC<= flash point <=60 degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | UNRTDG Class: 6.1 Subsidiary risks Class: 3 |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG Class: 6.1, Subsidiary risks Class: 3 |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | UNRTDG Class: 6.1; Subsidiary risks Class: 3 |
| 13 | Oxidizing liquids | Not classified | - | - | - | - | UNRTDG Class: 6.1; Subsidiary risks Class: 3 |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | UNRTDG Class: 6.1, Subsidiary risks Class: 3 |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on rabbit LD50 value: 17394mg/kg (RTECS, Access on Sep 2005), it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on guinea pig LC50 (1 hour): 300ppm (4 hour equivalent: 0.932mg/L) and guinea pig LC50 (4 hours): 95ppm (equivalent: 0.59mg/L) (ACGIH 7th, 2001 and Industrial Hygiene Society advice, 1993), the lower value was adopted. 95ppm (0.59mg/L) could be judged as the steam with almost no mist from vapor pressure, and classified as Category 1according to the ppm concentration standard. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was classified as Category 2 from description that the skin is stimulated seriously (ICSC (J) (1997), HSFS (1999), and SITTIG (4th, 2002)). |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
It was set as Category 1 from description that severe eye damage was acknowledged in human occupation evidence of exposure of ACGIH (7th, 2001). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory system, kidney) |
|
Warning | H371: May cause damage to organs (respiratory system, kidney) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the description that pulmonary edemas may be caused by inhalation in ICSC (J) (1997), HSFS (1999), and SITTIG (4th, 2002), it was classified into Category 2 (respiratory tracts). Moreover, due to the description that the renal effect was observed within the guidance value of Category 2 by oral administration in the rat in RTECS (2005). So it was classified into Category 2 (kidney). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, eye) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, eye) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Due to the description in ACGIH (7th, 2001) and Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1993) that the effects on the respiratory and on the eyes tract was seen with the concentration of the guidance value range of Category 1 in the four-week inhalation exposure test using the rat, respiratory systems and eyes were considered as target organ and it was classified in Category 1. However, as for the the change of kidney, liver, a spleen, and a thymus indicated in Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1993), since there was no statement in ACGIH (7th, 2001) though it was the same examination, they were not taken as target organ. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |