GHS Classification Result

Chemical Name：acetamide
CAS：60-35-5

Result：
ID: 218
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - The test which is suitable for the solid with a melting point of 81 degC (140 degC or less) has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: 130 g/kg REFERENCE SOURCE: IARC vol.7(1974)
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on descriptions "it has comparatively no irritativeness to the skin or mucous membrane (HSDB (2003))" and "the skin and eye are stimulated as effect of short-term exposure (ICSC (1997))", it was judged to have slight irritativeness and classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on description of "there is no irritation to mucosa comparatively (HSDB (2003))", and description "the skin and an eye are stimulated as effect of short-term exposure (ICSC (1997))", it was judged as slight irritation and set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Although the result of one of the three micronucleus tests in mouse bone-marrow cells (in vivo mutagenicity tests in somatic cells) was "marginally positive", negative results were obtained from the 2 other subsequently reported tests using higher dose. So the substance was regarded as outside the categories.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the category 2B by IARC (1999) as latest evaluation document, it was set as Category 2. In addition, it is classified into 2B in Japan Society for Occupational Health, and is classified into 3 in EU, respectively. Moreover, in the rat carcinogenicity test, increases of incidence of liver tumors are observed (IARC 71 (1999)).
7 Reproductive toxicity Classification not possible - - - - The effect to reproductive function or reproductive potential in premating administration is unknown, and it cannot be classified since data is insufficient, .
8 Specific target organ toxicity - Single exposure Not classified - - - - The highest tolerance doses after single time oral exposure is described to be 7.5g/kg and 8.0g/kg in the rat and the mouse, respectively (IARC vol.7 (1974)). Serious toxic influence dosage is at least more than the highest tolerated doses, and it exceeded the guidance value Category 2. So it was out of the Category.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - Insufficient data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 24-hour EC50>10g/L of the Crustacea (Daphnia magna), and others (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =2.25*106mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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