GHS Classification Result

Chemical Name:Tributyl phosphate
CAS:126-73-8

Result:
ID: 217
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 146degC (open cup flash test) (ICSC, 1999)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 410degC (ICSC, 1999)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (insoluble(ICSC,1999))
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to the absence of data, though being organic compounds containing oxygen bound to carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the LD50 value of 1,430mg/kg calculated from the testing data of rat LD50 (oral route) of 1,390mg/kg (SIDS (2004)), 1,400mg/kg (EHC 112 (1991)), 1,552mg/kg (EHC 112 (1991)), 3,000mg/kg (EHC 112 (1991)), and 3,350mg/kg (SIDS (2004)).
1 Acute toxicity (Dermal) Classification not possible - - - - Insufficient data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition.
1 Acute toxicity (Inhalation: Vapours) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LC50 (4 hours) value of 152ppm, calculated from the testing data of rat LC50 (inhalation of vapour) of 1.359mg/L (4 hours) (EHC 112 (1991)), was lower than 90% of the saturated vapour concentration (26,300ppm) under a saturated vapour pressure of 2.66kPa (20degC) (CERI Hazard Data 2000-56 (2001)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on rabbit skin irritation tests (EHC 112 (1991)): Erythema and edema are observed, along with severe irritation (though the results are not those of 4-hour application).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the description in the report on rabbit eye irritation tests (EHC 112 (1991)): "moderate irritant."
4 Respiratory sensitization Classification not possible - - - - Insufficient data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on germ cell multi-generation mutagenicity tests/mutagenicity tests in vivo and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in SIDS (2004), EHC 112 (1991).
6 Carcinogenicity Classification not possible - - - - Cannot be classified due to lack of existing classification.
7 Reproductive toxicity Not classified - - - - Based on the description in the report on rat two-generation and developmental toxicity tests (SIDS (2004)): No reproductive toxicity is observed, while the developmental toxicity is considered a secondary effect of maternal toxicity.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available
9 Specific target organ toxicity - Repeated exposure Category 2 (testis, urinary bladder, nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (testis, urinary bladder, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including "seminiferous tubule degeneration, epithelial hyperplasia in the mucous membrane of the bladder, a mild but significant decrease in the nerve conduction velocity in the tail, a reduction of the Schwann cell process in nonmyelinated sciatic nerves (observed through scanning electron microscopy)" (EHC 112 (1991)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 48 hours EC50=2.6mg/L of the crustacea (Daphnia magna) (SIDS, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=20(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information