GHS Classification Result

Chemical Name:4-Methyl-1,3-phenylene diisocyanate
CAS:584-84-9

Result:
ID: 209
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#2078)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures; the flashing point is 620degC (ICSC, 2004)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 22degC (ICSC,2004), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#2078)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 (oral route) value of 5,800mg/kg representing the lower of the two testing data, 6,170mg/kg (PATTY 4th, 2000) and 5,800mg/kg (ACGIH 7th, 2004).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the LC50 value (4 hours) of 897ppm, calculated from the testing data of rat LC50 (6 hour inhalation of dust/mist) of 4.27mg/L (PATTY 4th, 2000), exceeded the saturated vapor concentration (660 ppm) under a saturated vapour pressure of 67 Pa (25degC) (CERI Hazard Data 97-20, 1998), the substance is likely to contain mist, despite its description as vapour.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description of "severe" found in the RTECS report (2005) on rabbit skin irritation tests, suggesting that the substance induces at least mild skin irritation, although it is unclear whether the tests were 4-hour tests, and based on the fact that the substance is classified as "Xi (irritant)"by EU Risk Phrase.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the evidence of "severe irritation"in rabbit eye irritation tests (CERI Hazard Data 97-20, 1998) and "slight conjunctival irritation" and "stinging in the eyes, lacrimation"in human eye irritation tests (DFGOT Vol. 20, 2005), although the substance should be placed in Category 2A from the viewpoint of safety.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Due to the fact that the substance was classified as "Respiratory Tract Group 1" according to Recommendations by the Japan Society of Occupational Health (2005).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on positive results in guinea pig skin sensitization tests (EHC 75, 1987) and due to the fact that the substance is classified as "Skin Group 2" according to Recommendations by the Japan Society of Occupational Health (2005) and "SEN" by ACGIH-TLV (2005).
5 Germ cell mutagenicity Classification not possible - - - - Due to the lack of description on the type of cells (germ cells or somatic cells) used for in vivo tests in which positive results were obtained, although positive results were obtained for multiple indices in in vitro mutagenicity tests.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category A4 by ACGIH (2001), Group 2B by IARC 71 (1999) and Category 2B according to Recommendations by the Japan Society of Occupational Health (2004), and priority was given to the IARC classification, following the guidelines.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on human evidence including "the substance induces eye/skin/respiratory irritation and induces chemical bronchitis, pneumonia and pulmonary edema through inhalation of vapor" (ICSC (J) (1995)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, blood system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including "reversible hyperplasia in the larynx, squamous metaplasia, rhinitis, forced breathing, reversible hyperplasia in the trachea, necrotizing bronchitis, bronchiolitis, hyperplasia in the lung, metaplasia, dropsy, alveolitis, decrease in urinary output and urine protein levels, increases in blood nitrogen, hemoglobin and hematocrit levels and red blood cell counts, decreases in platelet and while blood cell counts" (DFGOT Vol. 20, 2004). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It was classified into Not classified from 96 hours LC50=164500microg/L of the fish (Fathead minnows) (MOE Risk Assessment vol. 1 (2002) and others.). In addition, methyl-1,3-phenylene diisocyanate (isomer mixture of this substance) was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since acute toxicity was classified into Not classified (acute toxicity is not reported within the aqueous solubility concentrations) and the bio-accumulation was low (BCF=380 (Existing Chemical Safety Inspections Data)), it was classified into Not classified. In addition, the chronic toxicity of methyl-1,3-phenylene diisocyanate (isomer mixture of this substance) was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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