GHS Classification Result

Chemical Name：Methyl methacrylate
CAS：80-62-6

Result：
ID: 204
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 10degC (open cup flash test) (ICSC, 2003) and the boiling point is 100.5degC, which is classified into Category 2. Those containing stabilizers are classified into Class 3 and Packing Group II (UN#1247) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though containing unsaturated bonds. Those containing stabilizers are classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1247)
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 421degC (ICSC, 2003)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available Those containing stabilizers are classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1247)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 (oral route) value of 7,900mg/kg representing the lower of the two testing data, 7,900mg/kg (ECETOC JACC30 (1995)) and 8,500mg/kg (ECETOC JACC30 (1995)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the testing data of rabbit LD50 (dermal route) of 5,000mg/kg or more (RTECS (2004)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LC50 (inhalation of vapour) value of 7,093ppm (ECETOC JACC30 (1995)) was lower than 90% of the saturated vapour concentration (52,000 ppm) under a saturated vapour pressure of 5.3 kPa (26degC) (Verschueren (2001)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. Also based on the description in ECETOC JACC30 (1995): Human volunteers exposed to low concentrations of methyl methacrylate (vapour inhalation) suffered respiratory irritation, developed hyposthenia and became feverish and dizzy.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on rabbit skin irritation tests (ECETOC JACC30 (1995)), with EU Risk Phrase Xi (R37/38) as a reference: Severe erythem, and moderate to severe edema with a dent in the center are observed after 24 hours of exposure; irritation caused by an application of 0.2 /kg disappears after 3 days of exposure; irritation caused by an application of 2 and 5g/kg does not disappear after 14 days of exposure.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (EU-RAR No.22 (2002), CERI Hazard Data 96-35 (1997). ACGIH (7th, 2001)): No effects are observed in the iris and cornea; reddening (Grade 2) is observed in the cornea after 24 hours of exposure; the substance is mildly to moderately irritating to rabbit eyes. The substance is thus considered "mildly to moderately irritating" to the eyes. Classified into 2A-2B because of the absence of data verifying the classification into 2A or 2B, although the substance should be placed in Category 2A from the viewpoint of safety.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Based on the classification by the Japan Society for Occupational Health (2004).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description in EU-RAR No.22 (2002) (The substance causes allergic dermatitis) and in the Japan Society for Occupational Health (The substance is a skin sensitization), with reference to EU Risk Phrase R43 (The substance may cause sensitization in contact with skin).
5 Germ cell mutagenicity Not classified - - - - Based on the negative data on multi-generation mutagenicity tests in vivo (dominant lethal tests) and the absence of data on germ cell mutagenicity tests in vivo, described in EU-RAR No.22 (2002), ECETOC JACC30 (1995). Somatic cell mutagenicity tests in vivo (chromosome aberration tests, micronucleus tests) suggest an increase in the incidence of gap-type aberrations. Each of these results, however, is considered "unreliable" or "insufficient to provide evidence of positive results," according to EU, ECETOC and CICAD. The results of somatic cell mutagenicity tests in vivo are thus considered "negative."
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 by IARC (1994), Category A4 by ACGIH (2001) and Group E by EPA (1998).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the teratogenicity studies in rats, the increase in early fetal deaths, reduced crown-rump length and hematomas were observed at the concentrations where matarnal toxicity such as death and loss of body weight was observed. Therefore, the substance was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "respiratory irritation, hyposthenia, fever, dizziness, nausea, headache, sleepiness" (EU-RAR No.22 (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "atrophic rhinitis, laryngitis, autonomic disorder, headache, dizziness, oversensitiveness, concentration lapses, memory lapses" (MOE Risk Assessment vol. 2 (2003)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48 hours EC50=69mg/L of the crustacea (Daphnia magna) (EU-RAR (2002) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 94.3% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=1.38 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information