Chemical Name:Phthalic anhydride
CAS:85-44-9
ID: | 202 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though classified as "flammable" by ICSC (2004) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 570degC (ICSC, 2004) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available (melting point: 131degC (ICSC, 2004), test temperature: 140degC) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 1,530mg/kg (MOE Risk Assessment vol. 2 (2003)). | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | Classification not possible because the rabbit LD50 (dermal route) values of >3,160mg/kg and >10,000mg/kg (IUCLID (2000)) are not definitive values. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | Because the rat LC50 (inhalation) value of >0.21mg/L (34ppm when the conversion factor of 1ppm = 6.16mg/m3 (20degC) was applied) (MOE Risk Assessment vol. 2 (2003)) exceeded the saturated vapour concentration (0.03ppm) under a saturated vapour pressure of 0.0003hPa (20degC), the substance was considered as "dust exposure." However, classification is not possible since the LC50 of >0.21mg/L is not a fixed value. |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 2000-54 (2001)): "The substance induced moderate irritation when applied to abraded skin." | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2000-54 (2001)): "severely irritating to the eye." Although classified into Category 1-2A in the absence of data on reversibility, the substance should be placed in Category 1 from the viewpoint of safety. | |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Due to the fact that the substance is reported as a "Respiratory Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy (2004). | |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the description in the report on Buehler tests and Intracutaneous tests on guinea pigs (CERI Hazard Data 2000-54 (2001)): "sensitization: positive." Also based on the overall conclusion made by CERI Hazard Data 2000-54 (2001): "The substance possesses a potential for sensitization for human skin." | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no positive data on mutagenicity tests in vitro (several indices). |
6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category A4 by ACGIH (2001). |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of adverse effects on sperm production, testes and epididymis, described in MOE Risk Assessment vol. 2 (2003) (though no data are available on maternal toxicity). | |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) | Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence: "burning sensation in the upper respiratory tract and coughing were noted immediately after accidental inhalation of high concentrations" (CERI Hazard Data 2000-54 (2001)). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "conjunctivitis, hemorrhagic rhinorrhea, nasal mucosal atrophy, coughing, bloody phlegm, bronchitis, pulmonary emphysema," "after the latency period of 16 years, 13 patients (11%) had chronic bronchitis and 21 (18%) had asthma," "the substance-induced asthma was observed" (CERI Hazard Data 2000-54 (2001)), "asthma occurred following exposure" (HSDB (2005)), "hemorrhagic rhinorrhea, nasal mucosal atrophy, hoarse voice, coughing, bloody phlegm, bronchitis and pulmonary emphysema" (ACGIH (7th, 2001)). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 72 hours ErC50=68mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 2003). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since there was rapidly degrading (the decomposition by BOD: 85.2% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=1.6 (PHYSPROP Database, 2005)), it was claasified into Not classified. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website (in Japanese Only) |