GHS Classification Result

Chemical Name:Phthalic anhydride
CAS:85-44-9

Result:
ID: 202
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as "flammable" by ICSC (2004)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 570degC (ICSC, 2004)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 131degC (ICSC, 2004), test temperature: 140degC)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 1,530mg/kg (MOE Risk Assessment vol. 2 (2003)).
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible because the rabbit LD50 (dermal route) values of >3,160mg/kg and >10,000mg/kg (IUCLID (2000)) are not definitive values.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Because the rat LC50 (inhalation) value of >0.21mg/L (34ppm when the conversion factor of 1ppm = 6.16mg/m3 (20degC) was applied) (MOE Risk Assessment vol. 2 (2003)) exceeded the saturated vapour concentration (0.03ppm) under a saturated vapour pressure of 0.0003hPa (20degC), the substance was considered as "dust exposure." However, classification is not possible since the LC50 of >0.21mg/L is not a fixed value.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 2000-54 (2001)): "The substance induced moderate irritation when applied to abraded skin."
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2000-54 (2001)): "severely irritating to the eye." Although classified into Category 1-2A in the absence of data on reversibility, the substance should be placed in Category 1 from the viewpoint of safety.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Due to the fact that the substance is reported as a "Respiratory Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy (2004).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the description in the report on Buehler tests and Intracutaneous tests on guinea pigs (CERI Hazard Data 2000-54 (2001)): "sensitization: positive." Also based on the overall conclusion made by CERI Hazard Data 2000-54 (2001): "The substance possesses a potential for sensitization for human skin."
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no positive data on mutagenicity tests in vitro (several indices).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 by ACGIH (2001).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of adverse effects on sperm production, testes and epididymis, described in MOE Risk Assessment vol. 2 (2003) (though no data are available on maternal toxicity).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence: "burning sensation in the upper respiratory tract and coughing were noted immediately after accidental inhalation of high concentrations" (CERI Hazard Data 2000-54 (2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "conjunctivitis, hemorrhagic rhinorrhea, nasal mucosal atrophy, coughing, bloody phlegm, bronchitis, pulmonary emphysema," "after the latency period of 16 years, 13 patients (11%) had chronic bronchitis and 21 (18%) had asthma," "the substance-induced asthma was observed" (CERI Hazard Data 2000-54 (2001)), "asthma occurred following exposure" (HSDB (2005)), "hemorrhagic rhinorrhea, nasal mucosal atrophy, hoarse voice, coughing, bloody phlegm, bronchitis and pulmonary emphysema" (ACGIH (7th, 2001)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 72 hours ErC50=68mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 2003).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 85.2% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=1.6 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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