GHS Classification Result

Chemical Name：1,2,4-Bbenzenetricarboxylic 1,2-anhydride
CAS：552-30-7

Result：
ID: 195
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as "flammable" by ICSC (1999).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the results of rat LD50 (oral route) of 2,030mg/kg representing the lower of the testing data, 2,030mg/kg and 3,340mg/kg (SIDS (2003)), and based on "reliable evidence showing that the results are within the range of Category 5."
1 Acute toxicity （Dermal） Not classified - - - - Based on the testing data of rat LD50 (dermal route) of 5,600mg/kg (SIDS (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (4 hours): "mild irritation was observed" (SIDS (2003)), and "mild irritation" (CERI Hazard Data 2001-33 (2002)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the evidence of "Severe eye irritation" (CERI Hazard Data 2001-33 (2002)), "the material should be considered severe eye irritants" (SIDS (2003)), and "TWAN into rabbit eye produced irritation scores of 105.6/110.0 on day 2 and 97.0/110.0 on day 7, a positive indicator that TWAN can produce ocular burns" (ACGIH (7th, 2001)) from the rabbit eye irritation test.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Based on the description in CERI Hazard Data 2001-33 (2002) of the human health effects: Allergic respiratory diseases were observed in 29% of the workers handling the substance, which is considered to cause respiratory sensitization.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description in the report on guinea pig skin sensitization tests (conducted in accordance with the maximization method and the murine lymph node assay) (CERI Hazard Data 2001-33 (2002)): Positive. The substance is considered to cause skin sensitization.
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on in vivo mutagenicity/genotoxicity tests and negative data on in vitro mutagenicity tests (chromosome aberration tests, mutation tests), described in SIDS (2003), NTP DB (Access on Feb., 2006).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - Insufficient data available (no data available on reproductive effects)
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "irritation to the upper respiratory tract (observed in those exposed to the substance)" (CERI Hazard Data 2001-33 (2002)), and the evidence from animal studies including "irregular respiration and temporary respiratory arrest (due probably to direct stimulation of the peripheral vagus nerve in the depth of the lungs)" (CERI Hazard Data 2001-33 (2002)), "red lesions, spots and fluid accumulation in the lungs" (SIDS (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, blood system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "allergic asthma, rhinitis, irritable respiratory conditions, pulmonary diseases, anemic conditions, late asthma, sneezing caused by irritation, nasal hemorrhage, cough, dyspnea" (CERI Hazard Data 2001-33 (2002)), "TMA-related pulmonary impairment, immune system responses" (SIDS (2003)), and the evidence from animal studies including "pulmonary hemorrhage, bronchial pneumonia" (CERI Hazard Data 2001-33 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It was classified into Not classified from 48 hours EC50>792mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (preliminary version), 2006).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was not water-insolubility (the water-solubility =1036mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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