GHS Classification Result

Chemical Name:Benzyl chloride
CAS:100-44-7

Result:
ID: 193
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The flash point is 67degC (c.c.) (ICSC, 2004), which is classified into Category 4.
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 585degC (ICSC, 2004).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Cannot be classified due to lack of data, though the substance acts on many metals in the presence of water according to ICSC (2004). Classified into "Corrosive Substances" by the UN Recommendations on the Transport of Dangerous Goods. However, the category includes skin corrosivity, and it is unclear whether the substance is classified as "metal" corrosive (UN#1738).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the LD50 value of 679mg/kg calculated from the testing data of rat LD50 (oral route) of 625mg/kg (CERI Hazard Data 97-4 (1998)), 1,660mg/kg (CERI Hazard Data 97-4 (1998)) and 1,231mg/kg (MOE Risk Assessment vol. 4 (2005)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LC50 (4 hours) value of 100ppm (0.52mg/L), calculated from the testing data of rat LC50 (inhalation of vapour) of 0.74mg/L (2 hours) (MOE Risk Assessment vol. 4 (2005)), 0.78mg/L (2 hours) (MOE Risk Assessment vol. 4 (2005)) and 0.77mg/L (ACGIH (7th, 2001)), was lower than 90% of the saturated vapour concentration (1,320ppm) under a saturated vapour pressure of 0.133kPa (22degC) (CERI Hazard Data 97-4 (1998)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in the report on 24-hour skin irritation tests in rabbits (SIDS (2002)): "severe flare followed by swelling and necrosis." Also based on the description of the human health effects (CERI Hazard Data 97-4 (1998)): "very strong irritation of the skin, eye and mucous membranes." The substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the description of the human health effects (MOE Risk Assessment vol. 4 (2005)): "The substance is corrosive to the eye. In the form of vapour, it causes irritation of the eye, skin and respiratory tract."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the description in the report on guinea pig skin sensitization tests (CERI Hazard Data 97-4 (1998) and SIDS (2002)): "Skin sensitization: positive."
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in IARC 71 (1999) and NTP DB (Access on March 2006).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category A3 by ACGIH (2001) and Category B2 by EPA (1994).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of body length reduction of the embryo, described in MOE Risk Assessment vol. 3 (2004), MOE Risk Assessment vol. 4 (2005), CERI Hazard Data 97-4 (1998) and SIDS (2002) (no data presented on maternal toxicity).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system) Danger H370: Causes damage to organs (respiratory system, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence: "strong irritation of the upper respiratory organs accompanied by coughing and dizziness; inhalation of high concentrations causes pulmonary edema, tetraplegia and loss of consciousness" (MOE Risk Assessment vol. 4 (2005)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory system), Category 2 (heart, liver, thyroid) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (heart, liver, thyroid)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence: "workers occupationally exposed to the substance exhibited debility, fatigue, persistent headache and increased excitability" (MOE Risk Assessment vol. 4 (2005)), and the evidence from animal studies including "necrosis of the cardiac muscle, severe hyperplasia, severe congestion and edema in the heart/lung/liver, a significant increase in the incidence of hyperplasia/focal necrosis of the cardiac muscle, degeneration of the thyroid gland, severe injury in the respiratory/olfactory epithelium, diffuse pulmonary edema" (MOE Risk Assessment vol. 4 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (respiratory organs) and Category 2 (heart, liver, thyroid gland).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=140microg/L of the crustacea (Marsupenaeus Japonicus) (MOE Risk Assessment vol. 3 (2004) and others.).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 70.9% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=2.3 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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