GHS Classification Result

Chemical Name:beryllium
CAS:7440-41-7

Result:
ID: 190
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although beryllium powder is classified into the class 4.2 of subsidiary risks according to UNRTDG, burning rate changes with size of the powders etc.. So it cannot be judged, without regular burning rate examination of a real sample. The acceptance criteria are as follows: The burning time with defined test: Category 1<=5 minutes; Category 2 >5 minutes and <= 10 minutes
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - UNRTDG Class: 6.1 Subsidiary risks Class: Class: 4.1 (Powdery Beryllium)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1 Subsidiary risks Class: Class: 4.1 (Powdery Beryllium)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - UNRTDG Class: 6.1 Subsidiary risks Class: Class: 4.1 (Powdery Beryllium)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1 Subsidiary risks Class: Class: 4.1 (Powdery Beryllium)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Since data is insufficient, it cannot classify. There is only a description in ATSDR (2002) that 20 out of 74 rats died on 12 - 15 days after from 50-minute inhalation exposure of 0.8 mg/L..
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Classified as Category 1 because the Japan Society for Occupational Health (2005) classifies this into the 1st group of respiratory tract sensitization.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Classified as Category 1 because the Japan Society for Occupational Health (2005) classifies this into the 2nd group of respiratory tract sensitization.
5 Germ cell mutagenicity Classification not possible - - - - No data available
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is classified into 2A according to Japan Society for Occupational Health (2005), and into category 2 in according to EU (Access on Oct 2005). But it is classified into 1 according to IARC (Access on Oct 2005), and into A1 according to ACGIH (7th, 2001), and into L (inhalation) according to EPA (IRIS (Access on Oct 2005)), and is classified into K according to NTP (NTP RoC (2005)). So it was set as Category 1A.
7 Reproductive toxicity Classification not possible - - - - Since data is insufficient, it cannot classify. Although CICAD 32 (2001), IARC 58 (1993), and IRIS (1998) have description of the epidemiological studies which deny the relasionship between the beryllium occupation exposure and a miscarriage/ premature delivery, it is not the evidence which can deny reproductive toxicity obviously.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
In the descriptions that the inflammation of the airways is observed by short-term exposure in human in EHC 106 (1990), CICAD 32 (2001), ACGIH (7th, 2001), DFGOT vol.3 (1992), PATTY (4th, 1994), IARC 58 (1993) and ATSDR (2002), and that severe chemical pneumonia may be caused. So it is judged that the target organs is respiratory system, therefore, it was classified into Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Due to the descriptions that in long-term evidence of exposure of the humans in EHC 106 (1990), CICAD 32 (2001), ACGIH (7th, 2001), DFGOT vol.3 (1992), PATTY (4th, 1994), IARC 58 (1993), IRIS (1998), and ATSDR (2002), Chronic beryllium disease of (berylliosis) is observed, target organ is judged respiratory systems, and it was classified into Category 1.
10 Aspiration hazard Classification not possible - - - - Insufficient data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 4, since it is a metal, behavior in water is unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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