GHS Classification Result

Chemical Name：Hexamethylenediamine
CAS：124-09-4

Result：
ID: 189
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as "flammable" by ICSC (2004). Classified into Class 8 (UN#2280 (solid)) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 305degC (ICSC, 2004).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 23 - 41degC (ICSC 2004), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Cannot be classified due to lack of data, though the substance acts on many metals in the presence of water according to ICSC (2004). Classified into "Corrosive Substances" by the UN Recommendations on the Transport of Dangerous Goods. However, the category includes skin corrosivity, and it is unclear whether the substance is classified as "metal" corrosive (UN#2280 (solid)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 772mg/kg calculated from the testing data of rat LD50 (oral route) of 980mg/kg (CERI Hazard Data 98-6 (1999)), 1,127mg/kg (SIDS (1996)), 750mg/kg (MOE Risk Assessment vol. 3 (2004)) and 800mg/kg (SIDS (1996)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 (dermal route) value of 1,110mg/kg (ACGIH (7th, 2001)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on several skin irritation tests with rabbits (SIDS (1996)): "Corrosive" (though the results are not those of 4-hour application). Also based on the description of the human health effects (MOE Risk Assessment vol. 3 (2004)): "Corrosive to the eye, skin and respiratory tract." The substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on eye irritation tests with rabbits (SIDS (1996)): "Corrosive." Also based on the description of the human health effects (MOE Risk Assessment vol. 3 (2004)): "Corrosive to the eye, skin and respiratory tract."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description of the human health effects: "Skin sensitization: positive," "induces allergic dermatitis." The substance is thus considered to possess a potential for sensitization for human skin, though guinea pig skin sensitization tests show negative (CERI Hazard Data 98-6 (1999) and SIDS (1996)).
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in SIDS (1996) and NTP DB (Access on March 2006).
6 Carcinogenicity Classification not possible - - - - Classification not possible given the insufficiency of data for use in classification, along with the absence of existing classification.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of reduced birth rates and delayed ossification in the filial generation at doses causing parental toxicity, described in MOE Risk Assessment vol. 3 (2004), ACGIH (7th, 2001) and SIDS (1996).
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system, nervous system, kidney) Warning H371: May cause damage to organs (respiratory system, nervous system, kidney) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence: "corrosive to the eye, skin and respiratory tract; inhalation may cause pulmonary edema." (ICSC (1998)), and the evidence from animal studies including "reduced locomotor activity, salivation, diarrhea and tremor; congestion of the kidney observed at necropsy" (CERI Hazard Data 98-6 (1996)), "decreased mobility, hyperpnoea and tremor" (SIDS (1996)). The ICSC study provides some evidence of human health effects under the heading of short-term exposure. However, the substance is classified into Category 2 since the priority rating of the study is 2, together with the absence of supporting case reports and information as to whether the effects are those of single exposure. The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, liver), Category 2 (blood system, kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, liver)
H373: May cause damage to organs through prolonged or repeated exposure (blood system, kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "irritation of the conjunctiva/upper respiratory tract and acute hepatitis" (CERI Hazard Data 98-6 (1999)), and the evidence from animal studies including "increased number of inflammatory cells in the nasal cavity, squamous epithelial hyperplasia of the respiratory epithelium, squamous epithelial hyperplasia and inflammatory cellular infiltration of the subepithelium in the trachea; alveolar decay, interstitial fibrosis, infiltration of the inflammatory cells in the lung" (CERI Hazard Data 98-6 (1999)), "sneezing, nasal catarrh and rale," "anemia accompanied by decreased WBC, degenerative changes in the kidney and liver" (SIDS (1996)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 72 hours ErC50=19mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals (2002) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by TOC: 96.9%(Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.35(PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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