GHS Classification Result

Chemical Name：Benomyl
CAS：17804-35-2

Result：
ID: 185
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Insufficient data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - Insufficient data available
11 Self-heating substances and mixtures Classification not possible - - - - Insufficient data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - It was set as the outside of Category. Because of rat LD50 value: >10000mg/kg, and death is not observed in 10000mg/kg or less (Agricultural-Chemicals abstracts).
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category. Since rat LD50 value was >5000mg/kg and death was not observed in 5000mg/kg or less (Agricultural-Chemicals abstracts).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since mild irritation was observed in the test on rats (Agricultural-Chemicals abstracts), it was classified as Category 3.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Classified as Category 1 because the skin sensitization test using guinea pigs showed 100% positive rate (agrochemical abstract).
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The dominant lethal test using rats, which is an in vivo multi-generation mutagenicity test using germ cells, is negative (Agricultural-Chemicals abstracts). And the experts investigated and confirmed the validity of the classification as Category 2 in EU and the classification of the substance's germ cell mutagenicity as Category 3A in MAK (Germany) (MAK/BAT, 2005), based on the data indicating that aneuploidy is induced in the test using mouse oocytes, which is an in vivo mutagenicity test using germ cells (Mailhes JB, & Aardema MJ; 1992). So the substance was classified as Category 1B
6 Carcinogenicity Not classified - - - - It is classified into A4 (ACGIH 7th, 2001) according to ACGIH and is classified into Group C according to EPA. So it was set as the outside of Category.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was the increase of the average of appearance ratio of malformation per litter, and hydrocephalus in the dose no maternal toxicity in the 7-to-16-day-pregnant oral administration to rat (Agricultural-Chemicals abstracts), it is classified into Category 1B. Moreover, there is the description that there was malformation of embryo in the dose no general toxicity to maternal animals in pregnant rat and mouse administration test (JMPR (1995)).
8 Specific target organ toxicity - Single exposure Not classified - - - - Since significant toxicity was not observed in taking orally and the transdermal medication examination using rat and mouse (Agricultural-Chemical abstracts), it was out of the Category.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since the effects on the liver was observed in the three-month oral feeding administration tests with this medicine 50% dosage using dog and the two-year oral feeding administration tests using dog (Agricultural Chemicals abstracts) within the dosage of the guidance value range of Category 2, it was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.012mg/L of fishes (American catfish) (EHC148, 1993).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (half life of carbendazim (hydrolysis product) was two months (under aerobic condition) and 25 months (under anaerobic condition) in water (EHC148, 1993)), though supposed less bioaccumulative(log Kow=2.12 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information