Chemical Name：2-tert-Butylimino-3-isopropyl-5-phenyltetrahydro-4H-1,3,5-thiadiazin-4-one; buprofezin
CAS：69327-76-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	From LD50 value (male/female: 1635/2015 mg/kg; male/female: 2198/2355 mg/kg) of two oral administration examinations using rat (Agricultural Chemical Registration Data (2001)), the lowest value was adopted (1635mg/kg), and it was set as Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	From the rat LD50 value >5000mg/kg of the dermal administration test (Agricultural Chemical Registration Data (2001)), it was set as the outside of Category.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 4		Warning	H332: Harmful if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	It was set as Category 4 based on LC50 value >4.57mg/L/4H using a rat of the inhalation exposure test (dust mists) (Agricultural Chemical Registration Data (2001)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Since only very slight erythema was found on one out of six rabbits in the skin irritation test (Agricultural Chemical Registration Data), it was classified as out of Category. (in addition, only a guinea pig skin irritation study is indicated in the Agricultural-Chemicals abstracts, and according to this finding, most skin irritation shall be disregarded).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Since reversible stimulativeness (redness, dropsy, iris change) was accepted as a result of the eye stimulativeness examination using a rabbit (Agricultural Chemical Registration Data(2001)), it was thought that there were mild eye irritancies, and was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Not classified	-	-	-	-	Classified as out of category because the result of a sensitization test using guinea pigs found no sensitization (Agricultural Chemical Registration Data (2005)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	The substance was regarded as outside the categories based on the negative results in the in vivo micronucleus test (Agricultural Chemical Registration Data, 2005) and in the in vitro reverse mutation test and the chromosome aberration test (Agricultural Chemical Registration Data, 2001).
6	Carcinogenicity	Not classified	-	-	-	-	Considering that carcinogenicity is not observed as a result of the carcinogenicity tests using rats and the mice for two years (Agricultural Chemical Registration Data (2001)), it was set as the outside of and Category.
7	Reproductive toxicity	Not classified	-	-	-	-	As a result of two generation reproduction study using rat, and of the teratogenicity test using rat and rabbit, there were not reproductive toxicity/teratogenicity (Agricultural Chemical Registration Data (2001)). So it was considered as on the outside of Categry.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	In two oral acute toxicity tests in rat (lowest dosage : 1021mg/kg or 1412mg/kg), although "reduced spontaneous locomotor activity, dacryorrhea, salivation, urinary incontinence, diarrhea, and no special mention at autopsy of the survival examples", or "reduced spontaneous locomotor activity at all dosage groups, dacryorrhea, and adhesions of the duodenal (site of perforation) and liver at autopsy of the survival examples" of were observed (Agricultural Chemical Registration Data (2001)), it is difficult to identify the specific target organs from these results presupposed. Therefore, it cannot be classified since data is insufficient.
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, liver, kidney, thyroid, brain)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (blood system, liver, kidney, thyroid, brain)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Since in the subacute toxicity study for 13 weeks using rats and dogs (Agricultural Chemical Registration Data (2005)), the decrease effect was observed in hemoglobin, hematocrit value and the number of the erythrocyte (in rat), and the increase effects was observed in organs weight (liver, kidney, thyroid gland) (in rat and dog), the abnormalities were observed histopathologically in these organs in rats. Moreover, histopathological abnormities were observed in rat brain (anterior pituitary). Since above observations were mainly observed at 1000 ppm or more (male: 85mg/kg/day, female:103mg/kg/day), they were classified into Category 2 (blood systems, liver, kidney, thyroid gland, brain).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=0.527mg/L of fishes (Carp) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.3(PHYSPROP Database, 2005)).