GHS Classification Result

Chemical Name：Di-n-butyl phthalate
CAS：84-74-2

Result：
ID: 182
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 157degC (c.c.) (ICSC, 2002)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 402degC (ICSC, 2002)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LD50 value of 6,300 mg/kg representing the lowest testing data of rat LD50 (oral route) of 6,300mg/kg and 8,000mg/kg, (EU-RAR No.29 (2003)), and over 20,000mg/kg (EHC 189, 1997). However acute toxicity was observed from a human case where a 23-year old male worker accidentally swallowed about 10g of the substance and suffered acute toxicity (EU-RAR No.29, 2003).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 (dermal route) of over 20,000 mg/kg (EU-RAR No.29 (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the rat LD50 (mist) of over 15.68 mg/L (EU-RAR No.29 (2003)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in CERI-NITE Hazard Assessment No.11 (2004) and EU-RAR No.29 (2003): The substance is "slightly to moderately irritating."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in CERI-NITE Hazard Assessment No.11 (2004) and EU-RAR No.29 (2003): The substance has irritation to eyes but recovery observed 48 or 72 hours later.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Phthalic acid di-n-butyl does not cause skin sensitization in experimental animals (EU-RAR No.29 (2003), EHC 189 (1997)); some human cases suggest positive results; classified into "Skin Sensitization Group 2" by the Japan Society for Occupational Health (2005), and into "Skin Sensitization: Positive" by the Japanese Society of Occupational Allergy.
5 Germ cell mutagenicity Not classified - - - - Based on the absence of positive data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo, described in CERI-NITE Hazard Assessment No.11 (2004).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category D by EPA (1993).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI-NITE Hazard Assessment No.11 (2004): Rat and mouse reproductive toxicity tests suggest a decrease in F0 reproductive potential, testis atrophy, a decrease in sperm production potential, abortion during the middle stages of pregnancy, a decrease in litter size; Rat and mouse teratogenicity tests suggest malformations in offspring (external/skeletal malformations), and developmental abnormalities in the testes and accessory reproductive gland of next-generation rats; General toxicity to parental animals is observed; No description is available for the effects on parental animals.
8 Specific target organ toxicity - Single exposure Category 1 (kidney, nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (kidney, nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "large amounts of red/white blood cells in urinary sediments" (CERI-NITE Hazard Assessment No.11 (2004)), and the evidence from animal studies including "constrained respiration, ataxia, local paralysis, convulsions, coma, fatal cases in some animals due to respiratory paralysis" (CERI-NITE Hazard Assessment No.11 (2004)), "obvious irritation to the upper respiratory tract mucous membrane" (EU-RAR No.29 (2004)). The effects on nervous system of experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system), Category 2 (testis, liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (testis, liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "seminiferous tubule degeneration, interstitial edema" (CERI-NITE Hazard Assessment No.11 (2004)), "hepatic atrophy and zonal necrosis" (EHC 189 (1997)), "dose-dependent acanthosis of the nasal mucous membrane" (EU-RAR No.29 (2004)). The effects on the respiratory organs and on the testes and liver of experimental animals were observed at dosing levels within the guidance value ranges for Category 1 and Category 2, respectively.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.46mg/L of the fish (American Catfish) (EU-RAR (2004) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 69% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (BCF=176 (Existing Chemical Safety Inspections Data)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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