GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,3-Butadiene
CAS：106-99-0
Result：
| ID: | 181 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
Based on the description in ICSC (2004): the lower explosion limit is 1.1vol%. Those containing stabilizers are classified into Division 2.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1010) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Classification not possible | - | - | - | - | No data available Those containing stabilizers are classified into Division 2.1 (UN Recommendations on the Transport of Dangerous Goods, UN#1010) |
| 5 | Gases under pressure | Liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | The boiling point is -4degC (ICSC 2004), and the critical temperature is 161.8degC (HSDB (2005)) - i.e., liquefied gas. Those containing stabilizers are classified into Division 2.1 (UN#1010)(UN Recommendations on the Transport of Dangerous Goods) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Classified as "gas" according to GHS definition |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Classified as "not classified," Based on the rat LD50 (oral route) of 5,480mg/kg (EU-RAR No.20 (2002)). 1,3-butadiene is a gas under ambient conditions, with its water solubility standing at 735mg/L (CERI-NITE Hazard Assessment No.9 (2005)). However, the method of oral administration is unknown and the data are not considered "reliable," hence classified as "classification not possible." |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | Based on the testing data of rat LC50 (4-hour inhalation of gas) of 129,000ppm (EU-RAR No.20 (2002)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Insufficient data available. Human cases are reported where exposure to 1,3-butadiene caused skin frostbite ((CERI-NITE Hazard Assessment No.9 (2005)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | The substances is considered "irritating" to rabbit and human eyes, based on the description in EU-RAR No.20 (2002), which also indicates that standard eye irritation tests cannot be performed because butadiene is a gas under ambient conditions. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Category 1B |
|
Danger | H340: May cause genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on positive data on multi-generation mutagenicity tests (mouse dominant lethal tests), described in EU-RAR No.20 (2002). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category K (Known to be human carcinogens) by NTP (2005). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Insufficient data available (no data available on the reproductive function of parent animals) |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation, Narcotic effects） |
|
Warning |
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence including "irritation to the eyes, nasal tract, larynx and lungs, associated with cough" (CERI Hazard Data 96-21 (1997)), and the evidence from animal studies including "mild narcotic influence" (CERI-NITE Hazard Assessment No.9 (2004)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (ovaria), Category 2 (blood system, heart, liver, bone marrow, testis) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (ovaria) H373: May cause damage to organs through prolonged or repeated exposure (blood system, heart, liver, bone marrow, testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "macrocytic megaloblastic anemia, ovarian atrophy, mineralization of the heart muscle, centrilobular hepatocyte necrosis, bone marrow atrophy, testis atrophy" (CERI-NITE Hazard Assessment No.9 (2004)). The effects on "ovaries" and "blood system, heart, liver, bone marrow and testes" are observed at dosing levels within the guidance value ranges for Category 1 and Category 2, respectively. |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Not applicable |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |