GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Pyridine
CAS：110-86-1
Result：
| ID: | 178 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flash point is 20degC (c.c.) and the boiling point is 115degC (ICSC (2000)), which is classified into Category 2. Classified into Class 3, Packing Group II (UN#1282) (UN Recommendations on the Transport of Dangerous Goods) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 482degC (ICSC, 2000) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | Classified into Class 3 (UN#1282) (UN Recommendations on the Transport of Dangerous Goods) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 895mg/kg calculated from the testing data of rat LD50 (oral route) of 891mg/kg, 1,580mg/kg (CERI Hazard Data 2001-70 (2002)), 1,500mg/kg (ACGIH (7th, 2004)) and 866mg/kg (IARC 77 (2000)). |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the guinea pig LD50 (dermal route) value of 1,000mg/kg representing the lower of the two testing data, 1,000mg/kg (MOE Risk Assessment vol. 3 (2004)) and 2,000mg/kg (ACGIH (7th, 2004)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the rat LC50 value of 4,450ppm (4 hours), calculated from the testing data of rat LC50 (4 hour-inhalation of vapour) of 12.898mg/L and 15.8mg/L (ACGIH (7th, 2004)), was lower than 90% of the saturated vapour concentration (27,400ppm) under a saturated vapour pressure of 2.77kPa (25degC) (CERI Hazard Data 2001-70 (2002)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 1A-1C |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 2001-70 (2002) and ACGIH (7th, 2004)): "severe damage" and "corrosion" (though no data are available on 4-hour application). The substance should be placed in Category 1A from the viewpoint of safety, if further subclassification is needed. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on eye irritation tests in rabbits and guinea pigs (CERI Hazard Data 2001-70 (2002), ATSDR (2000), PATTY (4th, 2000) and ACGIH (7th, 2004)): "severe damage," "corneal damage" and "severe injury." The substance is thus considered "corrosive." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Local Lymph Node Assay in guinea pigs show "positive" (CERI Hazard Data 2001-70 (2002)), while skin sensitization tests in guinea pigs are "negative" (ACGIH (7th, 2004)). These equivocal data do not allow the presence or absence of skin sensitization to be determined, and hence classification is not possible. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests and micronucleus tests), described in CERI Hazard Data 2001-70 (2002), NTP DB (Access on March 2006) and IARC 77 (2000). |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category A3 by ACGIH (2001). |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of atrophy of the testes/epididymis and prolonged estrus cycles, described in MOE Risk Assessment vol. 2 (2003) (though no data are available on parental toxicity). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, nervous system), Category 3 (narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (respiratory system, nervous system) H336: May cause drowsiness or dizziness (narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence including "pulmonary congestion and bronchitis," "effects on nervous system with speech disorder" (CERI Hazard Data 2001-70 (2002)), and the evidence from animal studies including "narcotic effects" (ACGIH (7th, 2001)). Evidence of respiratory toxicity was found following oral ingestion. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, kidney, nervous system), Category 2 (blood system) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, nervous system) H373: May cause damage to organs through prolonged or repeated exposure (blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "severe damage to the liver and kidney," "headache, dizziness, oversensitiveness, insomnia, nausea, vomiting, hepatopathy, cirrhosis, collapse of the nervous system with speech disorder" (CERI Hazard Data 2001-70 (2002)), and the evidence from animal studies including "inflammation of the liver" (CERI Hazard Data 2001-70 (2002)) and "anemia" (NTP TR470 (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 24-72 hours ErC50=0.069mg/L of the algae (Selenastrum) (CERI/NITE Hazard Assessment Report (preliminary version), 2006). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since there was rapidly degrading (the decomposition by BOD: 62% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.65 (PHYSPROP Database, 2005)), it was claasified into Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |