GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：4-Vinyl-1-cyclohexene
CAS：100-40-3
Result：
| ID: | 177 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flash point is 16degC (c.c.) and the boiling point is 130degC (ICSC (2004)), which is classified as Category 2. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though containing unsaturated bonds. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 269degC (ICSC, 2004). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the rat LD50 (oral route) value of 2,600mg/kg representing the lower of the two testing data, 2,600mg/kg (CERI Hazard Data 2000-15 (2001)) and 3,080mg/kg (PATTY (4th, 1999)). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on the rabbit LD50 (dermal route) value of 17,000mg/kg (CERI Hazard Data 2000-15 (2001)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Insufficient data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Based on a report on rabbit skin irritation test results (ACGIH (7th, 2001)): "moderately irritating." |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on a report on rabbit eye irritation test results (ACGIH (7th, 2001)): "focal corneal necrosis was observed." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in CERI Hazard Data 2000-15 (2001) and NTP DB (Access on March 2006). |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category A3 by ACGIH (2001), Group 2B by IARC (1994), Category 2B by Japan Society for Occupational Health. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in MOE Risk Assessment vol. 3 (2004), DFGOT vol.14 (2000) and ACGIH (7th, 2001): reduction in sperm count/mature follicle count was observed, though no descriptions are available regarding parental toxicity. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system), Category 2 (kidney) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (blood system) H373: May cause damage to organs through prolonged or repeated exposure (kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "change in WBC and decrease in hemoglobin levels," and the evidence from animal studies including "hyaline droplet degeneration of proximal renal tubules." The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data on dynamic viscosity, though the substance is a hydrocarbon. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 48 hours EC50=1.87mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (preliminary version), 2006). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=211(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |