Chemical Name:Nitroglycerin
CAS:55-63-0
ID: | 173 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Unstable Explosive | Danger | H200: Unstable Explosive |
P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P372: Explosion risk in case of fire. P374: Fight fire with normal precautions from a reasonable distance. P380: Evacuate area. P401: Store ... P501: Dispose of contents/container to ... |
UNRTDG, explosive substance assumed to be a transportation prohibition | |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified | - | - | - | - | UNRTDG, explosive substance assumed to be a transportation prohibition |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | It is classified into unstable explosive. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | It is known not to ignite spontaneously from the experience of manufacturing or in treatment, even if it contacts air in room temperatures. |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG, explosive substance assumed to be a transportation prohibition |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not classified | - | - | - | - | UNRTDG, explosive substance assumed to be a transportation prohibition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Although calculated based on rat oral LD50 value = 100mg/kg (CERI Hazard Data (2001)), 120mg/kg (CERI Hazard Data (2001)) and 822mg/kg (PATTY (1994)), the calculation values were lower than the lowest value of these data. Therefore 100mg/kg of the lowest value was adopted ,and it was set as Category 3. | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on rat percutaneous LD50 value >29200mg/kg (CERI Hazard Data (2001)), it was set as the outside of Category. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
3 | Serious eye damage/eye irritation | Category 2A-2B | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Although PATTY (1994) has the description with having no eye stimulativeness by application of the 7.29% of concentration solution to a rabbit, an eye is stimulated in humans (ICSC (J) (1995), HSFS (2001), and SITTIG (2002)). So it was set as Category 2A-2B. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Classified as Category 1 because PATTY (1994) describes that the Maximization test using guinea pigs found reactions in 40% of the animal. | |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | The substance was regarded as outside the categories based on the record of the negative dominant lethal test in rats (PATTY(1994)). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there is no effect to reproductive potential of F0 in three generation reproduction study of rat (HSDB (2005)), there is the increase of testicular interstitial cells and infertility by decreased hypoplasia in the male of the next generation in high dose group. And it was considered as in the Category 2. | |
8 | Specific target organ toxicity - Single exposure | Category 1 (cardiovascular system, blood) | Danger | H370: Causes damage to organs (cardiovascular system, blood) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the descriptions that hypotension and methaemoglobinaemia were reported as an acute intoxication in CERI Hazard Data (2001) and industrial hygene academic society advice (1986), that the hypotension in inhalation exposure example of the mixture of nitroglycerin and EGDN was observed in ACGIH (2001) and industrial hygene academic society advice (1986), and that it caused the angina in CERI Hazard Data (2001). So it is considered that the target organs are cardiovascular systems and blood, therefore, they were classified into Category 1. The intense headaches observed by occupational exposure was considered to be the secondary effect of this cerebral expansion. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Due to the description that in the epidemiological study of occpational exposure example in CERI Hazard Data (2001), ACGIH (2001), PATTY (1994) and industrial hygene academic society advice (1986), high mortality by the cardiovascular and cerebrovascular disease is reported, it is considered that target organ is cardiovascular system, and it was classified into Category 1. The headach observed by occupational exposure was considered to be the secondary effect of the cerebrovascular expansion. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 96-hour LC50=1.38mg/L of fishes (Bluegill) (CERI Hazard Data, 2002). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2, since acute toxicity was Category 2, and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=1.62(PHYSPROP Database, 2005)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |